نتایج جستجو برای: her 2
تعداد نتایج: 2593288 فیلتر نتایج به سال:
PURPOSE Therapeutic monoclonal antibody is increasingly applied in many clinical applications, although complicated technologies and high cost still limit their wide applications. To obtain the sustained serum antibody concentration with one single injection and lower the cost of antibody protein therapy, an adenovirus-mediated full-length antibody gene therapy was developed. EXPERIMENTAL DES...
background gastric dysplasia (gd) is a precursor lesion of gastric adenoâcarcinoma. intestinal type gastric carcinoma commonly shows microsatellite instability (msi) and the diffuse type is associâated with down regulation of e-cadherin. her-2/neu is over-expressed in some cases of gastric cancer. in this study, msi and expression rates of her-2/neu and e-cadherin in gd were evaluated. me t h...
زمینه و هدف: سرطان پستان شایع ترین سرطان در زنان می باشد. رشد و تمایز بافت طبیعی و بدخیم پستان به وسیله هورمون های استروئیدی و عوامل رشد از قبیل her-2/neu تنظیم می گردد. هدف از این مطالعه تعیین فراوانی بیان گیرنده استروژن، گیرنده پروژسترون و her-2/neu در یک جمعیت ایرانی مبتلا به سرطان پستان مهاجم بود.روش بررسی: این مطالعه به روش مقطعی- توصیفی روی 50 نمونه بیماران مبتلا به سرطان پستان مهاجم در ب...
introduction: breast cancer is the most common malignancy with more than one million new cases diagnosed annually all around the world. its growth is mostly regulated by steroid hormones such as estrogen and peptide growth factors in interaction with epidermal growth factor 1 and 2. methods and materials: in this study, 237 patients who had consulted the oncology clinic of tabriz university of ...
BACKGROUND Testing for human epidermal growth factor receptor-2 (HER-2) in breast cancer is performed by either immunohistochemistry (IHC) or in situ hybridization (ISH). The growth factor receptor-bound protein-7 (GRB7) gene is in close proximity to HER-2 on chromosome 17q11-12 and codes a signal transduction molecule shown to be an independent adverse marker in breast cancer. METHODS HER-2 ...
PURPOSE Tyrosine 1248 is one of the autophosphorylation sites of human epidermal growth factor receptor (HER)-2. We determined the prognostic value of the expression level of tyrosine 1248-phosphorylated HER-2 (pHER-2) in patients with HER-2(+) primary breast cancer using a reverse-phase protein array. PATIENTS AND METHODS The optimal cutoff value of pHER-2 for segregating disease-free surviv...
Genetic regulation of immune reactivity to Her-2 vaccination and the consequent antitumor effect was tested in human Her-2 transgenic (Tg) mice of C57BL/6 (B6), BALB/c (BALB), and (B6x BALB) F1 (F1) background. Mice were electrovaccinated with Her-2 DNA with or without pretreatment with CD25 monoclonal antibody to remove CD25(hi) regulatory T cells. When CD25(+) T cells were intact, BALB Her-2 ...
HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5-6 months of age. The development and histology of these tumors bears a striking resemblance to what is seen in patients with breast cancer. We have characterized the immunological responses to HER-2/neu (neu) in this animal model. neu-positive...
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