نتایج جستجو برای: hereditary breast cancer
تعداد نتایج: 1055993 فیلتر نتایج به سال:
Population with hereditary breast and ovarian cancer syndrome, i.e. BRCA1/2 mutation carriers, are at higher risk of developing breast and ovarian cancer as well as other solid tumours such as pancreatic cancer, prostate cancer and melanoma. With the increasing experience, screening recommendations and preventive strategies including prophylactic surgery are being settled. Surveillance of women...
Background . Breast cancer (BC) is the most common female malignancy worldwide. partner and localizer of BRCA2 gene ( PALB2 ) directly involved in DNA damage response. germline mutation has been identified breast familial pancreatic cases, accounting for approximately 1–2% 3–4%, respectively. goal this report was to describe new a young Yakut patient with family history cancer. Material methods...
Risk-reducing salpingo-oophorectomy for reducing future cancer risk in women with hereditary breast and ovarian cancer syndrome is rarely performed in Japan; therefore, the cancer preventive effect of risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancer syndrome among the Japanese population remains unclear. Here, we report the first case of serous tubal intraepithelial ...
The genetic etiology of hereditary breast cancer has not been fully elucidated. Although germline mutations of high-penetrance genes such as BRCA1/2 are implicated in development of hereditary breast cancers, at least half of all breast cancer families are not linked to these genes. To identify a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population, we ...
Hereditary breast-ovarian cancer syndrome contributes to as much as 5-7% of breast cancer (BC) and 10-15% of ovarian cancer (OC) incidence. Mutations in the "canonical" genesBRCA1andBRCA2occur in 20-30% of affected pedigrees. In addition toBRCA1andBRCA2 mutations, germ-line lesions in theCHEK2,NBS1, andPALB2genes also contribute to familial BC clustering. The epidemiology of hereditary breast-o...
As surgeons who care for patients with breast cancer, the possibility of a cancer diagnosis being related to a hereditary predisposition is always a consideration. Not only are we as surgeons always trying to identify these patients and families but also we are often asked about a potential hereditary component by the patients and their family members. It is therefore critical that we accuratel...
Hereditary and environmental variables have a role in the development of breast cancer. This study aimed to examine links between genetic Variations GSTP1 gene Predisposition cancer an Iraqi population. The research included 40 female patients 20 healthy volunteers. GSTP1-1695 A/G polymorphisms were investigated using polymerase chain reaction Real-time (RT-PCR). results showed frequency wild G...
The National Cancer Institute estimates that 12% of all women (about 1 in 8) will be diagnosed with breast cancer and 3% will be diagnosed with ovarian cancer throughout their lifetime.1,2 5-10% of all breast and ovarian cancers diagnosed are hereditary. Risk factors for hereditary breast and ovarian cancers include a family history with highly penetrant mutations in genes such as BRCA1 and BRC...
PURPOSE/OBJECTIVES To describe knowledge of hereditary, familial, and sporadic breast cancer risk factors among women in the community and to identify characteristics associated with this knowledge. DESIGN Descriptive, cross-sectional. SETTING Community settings in the San Francisco Bay Area. SAMPLE 184 women who had never been diagnosed with cancer, were 30-85 years old (mean = 47 + 12),...
Options for the prevention of hereditary breast and ovarian cancer include screening, preventive surgery and chemoprevention. Screening studies with magnetic resonance imaging of the breast are promising but the technology is not widespread and MRI is unlikely to be available as a screening tool in the near future. Prophylactic oophorectomy and mastectomy are effective preventive measures and a...
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