BACKGROUND We investigated whether hereditary thrombophilia is more prevalent in women with recurrent IVF-embryo transfer failures. METHODS This case-control study was conducted in an academic tertiary care hospital and compared 45 women with a history of four or more failed IVF cycles (group A) with 44 apparently healthy women matched for age and ethnic origin (group B). All participants wer...

Objective: Down Syndrome (DS) is defined as chromosome 21 trisomy and associated with cardiovascular system diseases. We aimed to study inherited thrombophilia genes (MTHFR A1298C, MTHFR C677T, Factor II G20210A, V Leiden G1691A, Cambridge G1091C, XIII, APOB, ITGB3, FVHR2, FGB, PAI-1 ACE) in patients DS. Materials Methods: A total of 53 DS (32 male female) were included the study. Demographical...

Pulmonary embolism (PE) is a common disease with high morbidity and mortality, yet it is a disorder that is difficult to diagnose (Stein & Matta, 2010). 90% of the clinical PE originates from the proximal deep veins of the lower extremities. An ultrasonographic study involving patients diagnosed with pulmonary embolism detected thrombus in 29% of the deep veins (Anderson et al., 1991). Failure ...

Y ou or a family member may have developed a blood clot in one of the deep veins in the body (ie, a deep vein thrombosis, or DVT) or had a blood clot that traveled to the lungs (ie, a pulmonary embolism, or PE). As part of your medical care, your doctor may have evaluated you for conditions that may have contributed to developing a blood clot. Thrombophilia is a condition in which there is an i...

The definition of thrombophilia includes the impact of hereditary base in the tendency to develop thrombosis and its clinical manifestations. Prothrombotic phenotype results from the interaction of inherited disorders of coagulation and various "clinical" risk factors such as obesity, immobility, major and minor surgery, hormone therapy, malignancy, etc. According to the accepted multicausal mo...

Hereditary thrombophilia is a rare disease of general population, which is responsible for debilitating consequences in severe cases. We present the case of a young male patient whose pathology and symptoms occurred since the age of two, which determined a venous insufficiency stage V with important limitation of the locomotors ability and plenty of complications. The aim of this paper is to dr...

OBJECTIVE We aimed to study the association among ABO blood group, von Willebrand factor, factor VIII plasma levels, and the risk of venous thrombosis (VT) in a cohort of 1774 relatives from 500 families with inherited thrombophilia. METHODS AND RESULTS One hundred sixty-one of the 1774 relatives had a VT. Different risk groups were formed: no, low-(factor V Leiden or F2G20210A heterozygous c...

BB Recurrent miscarriage is a common disorder that affects 1–3% of women of reproductive age; the prevalence can be up to 5% for women with 2 pregnancy losses. In a majority of these women, however, especially in those with early pregnancy losses, the causative factors for pregnancy loss can include chromosomal aberration of the fetus; anatomic abnormalities of the uterus; endocrine disorders, ...