Müller et al. studied corneal nerve morphology and endothelial cell density (ECD) in patients with and without unilateral herpes simplex keratitis (HSK). They demonstrated correlated reductions in corneal central ECD, subbasal nerve number and length, and sensation in both the affected and clinically unaffected contralateral eyes. They suggest a potential link between corneal innervation and en...

Ophthalmic findings are reported in 31 eyes of 28 children with herpes simplex keratitis. Twenty two had dendritic ulcers, and nine had geographic ulcers or disciform stromal keratitis. After resolution of keratitis, 80% (19/22) of children with dendritic ulcers achieved corrected visual acuity of 6/9 or better, 50% (11/22) had induced astigmatism, 45% (9/22) had one to five recurrences. In the...

Abstract Background and Aims: Herpes simplex virus (HSV) is a common cause of corneal disease and is the leading infectious cause of corneal blindness among developed nations. This study is aimed to provide an estimation of the incidence of Herpes Simplex Virustype-1, 2(HSV1, 2) and Varicella Zoster Virus (VZV) in tears and swab from eye infection by polymerase chain reaction (PCR) in eye ...

81 Topical cyclosporine as an alternative treatment for herpetic interstitial keratitis Ciclosporina tópica como alternativa eficaz en el tratamiento de las queratitis intersticiales herpéticas Dear Sir, Infection due to herpes simplex virus (HSV), also known as human herpes virus (HHV), continues to be the most frequent cause of corneal blindness in developed countries, where the prevalence ra...

Acanthamoeba keratitis is a type of protozoa keratitis caused by free-living fresh water Amoeba. It recently gains importance because of increasing incidence, difficulty in diagnosis and unsatisfactory treatment. It is seen more commonly in contact lens wear using homemade saline or may be in non-contact lens wearers due to swimming or bathing in contaminated water. This infection is commonly c...

We conducted a retrospective study of 107 penetrating keratoplasties in 99 eyes (99 patients) performed from 1970 to 1979 at the Wills Eye Hospital. The follow-up periods ranged from one to 12 years (median, three years). Overall, 86 of the 107 transplants (80%) remained clear and 63 eyes (59%) achieved good to excellent visual acuities (20/60 or better). Preoperative vascularization was not a ...

To the Editor: Reactivation of latent herpes simplex virus (HSV) has been described following radial keratotomy (RK) and following photorefractive keratectomy (PRK).1-4 Recently, one of my patients experienced such a complication 1 day after LASIK for hyperopia. The patient was a 60-year old caucasian female who had undergone 16-incision RK for myopia in her left eye elsewhere 10 years previous...

Topical application of 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (ara-HxMP) significantly inhibited the development of keratitis induced by types 1 and 2 herpes simplex virus and vaccinia virus in the eyes of rabbits. Parameters for evaluation of efficacy were infectivity (corneal opacity, lesion size, and type), Draize (erythema, conjunctival swelling, and discharge), and reductio...

The importance of specific immunity, especially cell-mediated, in resistance to herpes simplex disease is well documented, and animal experiments show that immune responses to previous herpetic infection can give considerable protection against reinfection in epithelial keratitis. Since susceptibility to stromal herpetic keratitis is probably determined in part by the extent of virus proliferat...