p-Dodecylbenzenesulfonic acid (DBSA) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. The present method was operationally si...

p-Dodecylbenzenesulfonic acid (DBSA) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. The present method was operationally si...

.................................................................................................................ix Chapter 1: Design, synthesis and evaluation of novel piperidine derivatives for monoamine transporter affinity .......................................................................................................................... 1 1.1. Abstract ..................................

A novel approach to the preparation of imidazole-substituted cyclic iodonium salts has been developed via oxidative cyclization 1-phenyl-5-iodoimidazole using a cheap and available Oxone/H2SO4 system. The structure new polycyclic heteroarenes confirmed by single-crystal X-ray diffractometry, revealing characteristic features for salts. newly produced imidazole-flanked compounds were found readi...

p-dodecylbenzenesulfonic acid (dbsa) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial knoevenagel, subsequent micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. the present method was operationally si...

Aim. DNA-encoded libraries technologies (DELT) are gradually becoming an important part of standard drug discovery toolbox. DELT is looking to find its place between classic low-molecular-weight candidates on the one hand, and high-molecular-weight antibodies peptides other hand. On natural path overcoming “childhood diseases” typical for every novel technology, has reached a point where chemic...

Twenty spirodiclofen analogues have been designed and conveniently synthesized via three steps including esterification, one-pot heterocyclization, and acylation reactions. The target molecules have been identified on the basis of analytical spectra (H NMR, C NMR and ESI-MS) data. All newly synthesized compounds have been screened for their potential insecticidal and herbicidal activity by stan...

A series of steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone were designed and prepared by a convenient heterocyclization reaction. The in vitro anticancer activities for these obtained compounds were evaluated against human cancer cell lines (HepG2, Huh-7, and SGC-7901), which demonstrated that some of these heterocyclic pyrimidine derivatives exhibited significantly good cyto...

A series of novel pyrazolodibenzo[1,4]diazepines has been synthesized with good overall yields. The diarylpyrazole intermediates, with structure similarity to biologically relevant compounds such as currently marketed drugs like rimonabant or celecoxib, were prepared by a tandem sequence amine-exchange/heterocyclization starting from readily available enaminones and arylhydrazines. The key step...