Mammary fat is the main composition of breast, and is the most probable candidate to affect tumor behavior because the fat produces hormones, growth factors and adipokines, a heterogeneous group of signaling molecules. Gene expression profiling and functional characterization of mammary fat in Chinese women has not been reported. Thus, we collected the mammary fat tissues adjacent to breast tum...

Cathepsin-D (CathD) is an aspartyl lysosomal protease expressed in all tissues that might play a role in antigen processing, cell proliferation and tissue renewal, and activation of different pro hormones. The aim of our study was to compare the expression of CathD in most common breast tumors and tumor-like breast lesions. The study includes 21 patients with histologically verified breast lesi...

background : breast carcinoma is the most common malignant tumor and leading cause of cancer deaths in women. while fine needle aspiration cytology is highly accurate in the diagnosis of breast lesions, it possesses certain drawbacks. in those circumstances intraoperative imprint cytology assumes importance, however, imprint cytology is subjected to interpretative errors. computer image analysi...

abstract objective: evaluating the usefulness of the triple test score (tts) in breast lesions. materials and methods: medical records of 100 cases were evaluated and tts was calculated based on of physical examination, mammography and fine-needle aspiration cytology findings. the diagnostic value of tts was assessed according to histopathology results. results: of the 23 lesions with score of ...

Biopsy of breast lesions only visible on MRI may benefit from patient-specific finite-element modeling the breast. This requires acquisition heterogeneous elasticity distribution. An acoustically transparent pad has been developed which enables strain elastography imaging using ultrasound without need for additional force or pressure sensors. The is known a priori while change in thickness dete...

Hamartoma of the breast is a rare benign breast lesion which is unfamiliar to most clinicians, although the mammographic features are usually characteristic. Hamartomas are composed of ducts, lobules, fat and fibrous tissue. These benign lesions are likely to be increasingly diagnosed because of routine screening and hence clinical awareness is paramount to prevent these lesions from being ...

background: sonoelastography (se) is introduced as a complementary technique for ultrasoungraohy (us) to evaluate breast lesions. this method is based on tissue strain in response to compression and decompression. the current study was designed to investigate the diagnostic performance of se for differentiating between benign and malignant breast lesions methods: a total of 35 women with 45 bre...

To characterize imaging features of pure DCIS on dynamic contrast-enhanced MR imaging (DCE-MRI), 31 consecutive patients (37-81 years old, mean 56), including 2 Grade I, 16 Grade II, and 13 Grade III, were studied. MR images were reviewed retrospectively and the morphological appearances and kinetic features of breast lesions were categorized according to the ACR BI-RADS breast MRI lexicon. DCE...

There is evidence that breast cancer is a heterogeneous disease phenotypically as well as molecular biologically. So far, heterogeneity on the molecular biological level has not been investigated in potential precursor lesions, such as ductal hyperplasia (DH) and ductal carcinoma in situ (DCIS). In this study we applied comparative genomic hybridization (CGH) to formalin-fixed, paraffin-embedde...

Background: India is facing challenging situation because the incidence of breast cancer has increased by 14% and mortality rate 11.1%. Breast- i a new tool for effective screening, especially detecting both non-palpable very small lesions often missed Clinical Breast Examination (CBE). This device expected to help in tiny outpatient clinic itself, helping reducing morbidity associated with lat...