AIM To investigate the role of DCC gene inactivation in the development and progression of gastric cancer. METHODS Loss of heterozygosity and loss of expression of the DCC gene was studied in 51 surgical specimens of gastric cancer using detection based on polymerase chain reaction. RESULTS Loss of heterozygosity was found in 35.3% (18 of 51) of specimens and was detected more often in stag...

In the mid-1960s protein electrophoresis revolutionized the study of population genetics and evolution. This technique revealed an extensive amount of genetic polymorphism existing in natural populations and, at the same time, provided a powerful tool to examine the evolutionary relationships of closely related species.1’2 In 1972 I developed a statistical method by which one can measure the ge...