In heart failure (HF), arrhythmogenic Ca(2+) release and chronic Ca(2+) depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR Ca(2+)-release channel. Dantrolene, a therapeutic agent used to treat malignant hyperthermia associated with mutations of the skeletal muscle type 1 RyR (RyR1), has recently been suggested to have effects on the car...

Maxwell JT, Domeier TL, Blatter LA. Dantrolene prevents arrhythmogenic Ca release in heart failure. Am J Physiol Heart Circ Physiol 302: H953–H963, 2012. First published December 16, 2011; doi:10.1152/ajpheart.00936.2011.—In heart failure (HF), arrhythmogenic Ca release and chronic Ca depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR C...

[1] Here we present electron temperature variations observed with incoherent scatter radar during a European Incoherent Scatter Scientific Association Heating experiment with high‐frequency (HF) radio wave transmission at frequencies above the peak ionospheric critical frequency. The electron temperature increased from 2000 K up to 2800 K during the HF transmission periods. During the experimen...

We report Hartree-Fock HF -based pseudopotentials suitable for plane-wave calculations. Unlike typical effective core potentials, the present pseudopotentials are finite at the origin and exhibit rapid convergence in a plane-wave basis; the optimized pseudopotential method A. M. Rappe et al., Phys. Rev. B 41, 1227 1990 improves plane-wave convergence. Norm-conserving HF pseudopotentials are fou...

[1] ELF/VLF radio waves (300 Hz–30 kHz) are difficult to generate with practical antennae, because of their extraordinarily long (10–1000 km) wavelengths, and the lossy nature of the Earth’s surface at these frequencies. ELF/VLF waves have been successfully generated via amplitude modulated (AM) HF (2–10 MHz) heating of the lower ionosphere. Through the temperature-dependent conductivity of the...

BACKGROUND Endothelial dysfunction is implicated in the pathophysiological features of heart failure (HF), and ethnic differences in the presentation of cardiovascular disease are evident, with an excess seen among South Asians (SAs). However, data on ethnic differences in endothelial function in HF are limited. METHODS AND RESULTS In a cross-sectional study, we recruited 128 subjects with sy...

The effects of acoustic and visual stimuli and their synergistic effects on heart rate variability including gender differences were investigated. Of particular interest was the influence of visual stimulus on heart rate variability during listening to simple sounds of different characters. Twelve male and 12 female university students were selected as subjects. The subjects listened at rest to...

penfluridol, a neuroleptic drug, considerably reversed halofantrine resistance in t9.96hf halofantrine resistant strain of plasmodium falicparum (originally chloroquine sensitive parasites), but not in k1hf halofantrine resistant strain (originally chloroquine resistant parasites)

BACKGROUND Right ventricular (RV) systolic function has been recognized as a prognostic factor in endstage heart failure (HF) patients and in the present study we evaluated the effect of this dysfunction on prognosis in patients with newly-diagnosed systolic HF. METHODS AND RESULTS We enrolled 180 consecutive patients with newly diagnosed systolic HF (ischemic or dilated cardiomyopathy). Echo...