Based on the natural sequence of Araneus diadematus Fibroin 4 (ADF4), the recombinant spider silk protein eADF4(C16) has been engineered. This highly repetitive protein has a molecular weight of 48kDa and is soluble in different solvents (hexafluoroisopropanol (HFIP), formic acid and aqueous buffers). eADF4(C16) provides a high potential for various technical applications when processed into mo...

Although the membrane-associated surfactant protein B (SP-B) is an essential component of lung surfactant, which is itself essential for life, the molecular basis for its activity is not understood. SP-B's biophysical functions can be partially mimicked by subfragments of the protein, including the C-terminus. We have used NMR to determine the structure of a C-terminal fragment of human SP-B th...

The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the nee...

Stereoselective synthesis of 5-7 membered cyclic ethers was achieved by deiodonative ring-enlargement of cyclic ethers having an iodoalkyl substituent. The reaction took place readily under mild conditions using hypervalent iodine compounds and an acetoxy or a trifluoroacetoxy group was introduced into the rings depending on the hypervalent iodine reagent employed. The use of hexafluoroisopropa...

The application of Raman spectroscopy to characterize natively unfolded proteins has been underdeveloped, even though it has significant technical advantages. We propose that a simple three-component band fitting of the amide I region can assist in the conformational characterization of the ensemble of structures present in natively unfolded proteins. The Raman spectra of alpha-synuclein, a pro...

Graphical Abstract Electrospun PES/PANI nanofibers were fabricated with three solvents and different PES concentrations. HFIP the lowest boiling point surface tension was best solvent for preparing highly conductive fluffy PANI in comparison to other solvents. 3D supported cellular infiltration proliferation.

Rechargeable magnesium batteries are gaining attention as promising candidates for large-scale energy storage applications because of their potentially high energy, safety and sustainability. However, the development Mg is impeded by lack efficient cathode materials compatible electrode-electrolyte combinations. Herein, we demonstrate a new poly(1,4-anthraquinone)/Ketjenblack composite (14PAQ@K...

A transition metal-free method for the cycloisomerization of propargylic amides to oxazoles was developed. The reaction utilizes in situ generated hydrogen chloride hexafluoroisopropanol (HFIP). With aid Design Experiments optimization a wide range substrates transformed into desired oxazoles. allows product formation without side reactions eliminating need extensive work-up and purification.

A protocol for the C−H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the orthoselective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and m...