Mercury (Hg) is a global pollutant and poses a worldwide concern due to its high toxicity. Guizhou province is recognized as a heavily Hg-polluted area in China due to both the special geochemical background and human activities. Here an integrated overview of current knowledge on the behavior of Hg in environments, as well as human health risk with respect to Hg contaminations in Guizhou was p...

Mercury (Hg) contamination is a global issue with implications for both ecosystem and human health. In this study, we use a new approach to link Hg exposure to health effects in spotted gar (Lepisosteus oculatus) from Caddo Lake (TX/LA). Previous field studies have reported elevated incidences of macrophage centers in liver, kidney, and spleen of fish with high concentrations of Hg. Macrophage ...

BACKGROUND Although a long latency period of toxicity after exposure to methylmercury (MeHg) is known to exist in humans, few animal studies have addressed this issue. Substantiation of delayed MeHg toxicity in animals would affect the risk evaluation of MeHg. OBJECTIVES Our goal in this study was to demonstrate the existence of a latency period in a rodent model in which the toxicity of peri...

This work investigated the toxicity of inorganic mercury and zinc preventive effects in female rats sacrificed 12 or 48 h after HgCl2 exposure. Female Wistar rats were subcutaneously injected with ZnCl2 (27 mg/kg) or saline (0.9 %), and 24 h later they were exposed to HgCl2 (5 mg/kg) or saline (0.9 %). Rats sacrificed 12 hours after Hg administration presented an increase in kidney weight and a...

pollution deriving from trace elements (cd, cu, ni, pb, zn, hg, as and cr) in sediment samples(collected in 2009), belonging to rivers located in catalonia and the basque country (spain), was assessedaccording to sediment quality guidelines. sediment samples were ranked in terms of a pollution index thattakes into account the presence of multiple pollutants such as trace elements. while only ab...

Transmembrane drug export mediated by the ATP-binding cassette (ABC) transporter P-glycoprotein contributes to clinical resistance to antineoplastics. In this study, we identified the substituted quinoline HG-829 as a novel, noncompetitive, and potent P-glycoprotein inhibitor that overcomes in vitro and in vivo drug resistance. We found that nontoxic concentrations of HG-829 restored sensitivit...

The development of large-scale mining activity along the Central Andes Argentina (CAA) has generated significant amounts waste materials containing heavy metals. Phytoremediation is a promising eco-friendly, low-cost, and effective technology for removal present study aimed to identify two native dominant species from CCA, Adesmia subterranea A. pinifolia, as metal-tolerant plant first time, by...