Clinical studies have demonstrated that high dose adjuvant interferon therapy improves disease-free and overall survival among high risk (stage IIb and III) melanoma patients. Sentinel lymph node mapping (SLM) has been shown to accurately detect micrometastasis and may be used to identify higher risk stage II patients, who might benefit most from adjuvant interferon therapy. We modelled the cos...

given preliminary evidence of timed, sequential chemotherapy of high dose cytosine arabinoside the current study was initiated to assess the side effects and efficacy of this regimen in patients with newly acute myelocytic leukemia (aml). nineteen adults who referred to hematology-oncology and bone marrow transplantation (bmt) research center of tehran university of medical sciences were enroll...

experimental  allergic encephalomyelitis (eae) is considered  as the murine model of multiple sclerosis. daidzein a phytostrogenic compound of soy is known to impose immunomodulatory and antioxidative effects. we conducted this study to assess the potential protective and therapeutic effects of daidzein on allergic encephalomyelitis. c57bl/6 mice  were induced  with  allergic encephalomyelitis ...

high-dose extended-interval dosage (hded) regimen of aminoglycosides is now considered as the standard dosage strategy in sepsis. although safety and efficacy of this dosing regimen is well studied, but new experiments show increased the risk of resistance development associated with %t>mic less than 60% of the dosing interval following extended interval dosing. moreover, limited information is...

This international, randomized, active-controlled, parallel-group, double-blind dose-finding study compared peginterferon alfa-2b (PegIntron) to interferon alfa-2b for the initial treatment of compensated chronic hepatitis C. We randomly assigned 1,219 subjects to receive either the standard three-times-weekly (TIW) interferon alfa-2b dose (3 MIU) or the once-weekly (QW) peginterferon alfa-2b (...

To study the effect and mechanism of Baitouweng decoction, mesalamine its combination with an enema in treatment ulcerative proctitis rats is objective study. The were divided into seven groups: Control (Normal), model (ulcerative proctitis), mesalamine, lowdose decoction combined medium-dose high-dose group. Except for control group, all induced a 5 % acetic acid solution proctitis. severity w...

2-Amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166) induced high levels of circulating interferon in mice when administered either parenterally or orally. Peak titers of interferon were found in the serum between 6 and 12 h after inoculation of the drug. Lower but significant levels of interferon were found in rat serum after administration of U-25,166 by either the intraperitoneal or oral route,...