An antibody that specifically interacts with an antigen could be applied to an active targeting delivery system. In this study, CD147 antibody was coupled with α-hed chitosan nanoparticles (α-Hed-CS-NPs). α-Hed-CS-CD147-NPs were round and spherical in shape, with an average particle size of 148.23 ± 1.75 nm. The half-maximum inhibiting concentration (IC50) of α-Hed-CS-CD147-NPs in human liver c...

OBJECTIVE This study extends previous research on masculinity and negative drinking consequences among young men by considering mediating effects of heavy episodic drinking (HED) and alcohol expectancies. We hypothesized that masculinity would have a direct relationship with negative consequences from drinking as well as indirect relationships mediated by HED and alcohol expectancies of courage...

Blast-wave-driven hydrodynamic instabilities are studied in the presence of a background B-field through experiments and simulations high-energy-density (HED) physics regime. In conducted at Laboratoire pour l’utilisation des lasers intenses (LULI), laser-driven shock-tube platform was used to generate hydrodynamically unstable interface with prescribed sinusoidal surface perturbation, short-pu...

Over the past five decades, per capita caloric intake has increased by approximately 28% in the United States. Excessive intake of calories from fats and sugars (high energy diets; HEDs) negatively impacts hippocampal-dependent memory. These deleterious effects of HEDs on hippocampal function involve HED-induced decreases in neuronal growth factors, neurogenesis, and synaptic plasticity. Given ...

X-ray spectra of high energy density ~HED! Z-pinch plasmas have been analyzed by means of a comprehensive kinetic modeling. A new diagnostic, x-ray spectropolarimetry, was applied to study anisotropy of Z-pinch plasma. This diagnostic is based on theoretical modeling of polarization-dependent spectra measured simultaneously by spectrometers with different sensitivity to polarization. Specifical...

BACKGROUND The goal of the present study was to directly compare the new radiopharmaceutical agent [(11)C]epinephrine (EPI) with [(11)C]hydroxyephedrine (HED) through the use of PET. METHODS AND RESULTS Seven healthy volunteers and 10 patients were investigated after heart transplantation. PET images of both tracers were of excellent quality in the volunteers. Values for radiolabeled metaboli...

We investigate parametric processes in magnetized plasmas, driven by a large-amplitude pump light wave. Our focus is on laser–plasma interactions relevant to high-energy-density (HED) systems, such as the National Ignition Facility and Sandia MagLIF concept. present self-contained derivation of “parametric” dispersion relation for three-wave interactions, meaning wave included equilibrium, simi...

Mismatch between areas of reduced myocardial blood flow (MBF) and reduced myocardial innervation (’defect’ areas) may be used to predict ventricular arrhythmias. The presence of a mismatch zone can be derived from a combined protocol consisting of both an MBF and [C]-meta-hydroxyephedrine ([C]HED) scans. The rate of influx of [C]HED from blood to myocardium (K1) is proportional to MBF and could...

Background—The goal of the present study was to directly compare the new radiopharmaceutical agent [C]epinephrine (EPI) with [C]hydroxyephedrine (HED) through the use of PET. Methods and Results—Seven healthy volunteers and 10 patients were investigated after heart transplantation. PET images of both tracers were of excellent quality in the volunteers. Values for radiolabeled metabolites (measu...

The Dawn spacecraft mission has provided extensive new and detailed data on Vesta that confirm and strengthen the Vesta–howardite–eucrite–diogenite (HED) meteorite link and the concept that Vesta is differentiated, as derived from earlier telescopic observations. Here, we present results derived by newly calibrated spectra of Vesta. The comparison between data from the Dawn imaging spectrometer...