David M. Ramirez,1 Alejandro W. Rodriguez,2,3 Hila Hashemi,2 J. D. Joannopoulos,1 Marin Soljačić,1 and Steven G. Johnson2 1Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3School of Science and Engineering, Harvard University, Cambridge, MA 02139, USA (Received 29 N...

In this work we consider the regulation system present on the SPI1 pathogenicity island of Salmonella enterica serovar Typhimurium. It is well-known that HilA is the central regulator in the overall scheme of SPI1 regulation and directly binds to virulence operons and activates their expression. The regulation of the expression of HilA is via a complex feed-forward loop involving three transcri...

M.C., M.A., M.D., D.Sc., LL.D., F.R.C.S.(Ed.), F.R.S.E. (Pp. xvi + 100; plates 30. 30s.) Edinburgh: E. & S. Livingstone, 1955. AN atlas and text on the sites and mode of entry of the principal arteries and nerves supplying the limb muscles has been compiled from new observations carried out at Edinburgh, Aberdeen, Leeds, and Glasgow on dissecting-room material, and from special dissections and ...

Salmonella enterica serovar Typhimurium uses the Salmonella pathogenicity island 1 (SPI1) type III secretion system to induce inflammatory diarrhea and bacterial uptake into intestinal epithelial cells. The expression of hilA, encoding the transcriptional activator of the SPI1 structural genes, is directly controlled by three AraC-like regulators, HilD, HilC, and RtsA, each of which can activat...

The evolution of bacterial pathogenicity, heavily influenced by horizontal gene transfer, provides new virulence factors and regulatory connections that alter bacterial phenotypes. Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) are chromosomal regions that were acquired at different evolutionary times and are essential for Salmonella virulence. In the intestine of mammalian hosts, S...

The type III secretion system (T3SS) encoded at the Salmonella pathogenicity island 1 (SPI-1) locus secretes protein directly from the cytosol to the culture media in a concerted, one-step process, bypassing the periplasm. While this approach is attractive for heterologous protein production, product titers are too low for many applications. In addition, the expression of the SPI-1 gene cluster...

Studia Judaica » 2020 Nr 2 (46) Halina Hila Marcinkowska, Wieczni tułacze. Powojenna emigracja polskich Å»ydów, Prószyński i S-ka, Warszawa 2019, ss. 424. A

The degeneration of acetylcholinesterase-positive nerve fibers in 11 canine renal autotransplants was investigated with the thiocholine method of Karnovsky and Roots as modified for cryostat sections. Seven renal hila were also examined by silver impregnation and thiocholine techniques. Total denervation was demonstrated in only 3 of 11 autotransplants; the other 8 showed variable degrees of de...

Salmonella enterica serovar Typhimurium secretes virulence factors for invasion called Sip proteins or Sips into its hosts through a type III secretion system (T3SS). In the absence of a host, S. enterica induces Sip secretion in response to sucrose or simple salts, such as NaCl. We analyzed induction of host-independent Sip secretion by monitoring protein secretion by sodium dodecyl sulfate-po...