Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recovery, a...

Objective(s): Nanoparticles of iron oxide (nFe2O3) are widely used in medicine and industry and could interfere with the brain processes associated with memory. The involvement of muscarinic cholinergic receptors in the process of memory formation has been confirmed. The present study aimed to investigate the possible interference of the cholinergic muscarinic receptors of the dorsal hippocampa...

Hippocampal information processing is often described as two-state, with a place cell state during movement and a reactivation state during stillness. Relatively little is known about how the network transitions between these different patterns of activity during exploration. Here we show that hippocampal network changes quickly and continuously as animals explore and become familiar with initi...

objective(s) nicotinic acetylcholine receptors (nachrs) regulate epileptiform activity and produce a sustained pro-epileptogenic action within the hippocampal slices. in the present study, we investigated the effect of nachrs on evoked glutamatergic synaptic transmission in area ca3 and ca1 of rat hippocampal slices to identify possible excitatory circuits through which activation of nachrs pro...

Occlusal disharmony is induced by various conditions such as the loss of teeth and inappropriate vertical dimension of crowns, bridges, or dentures. Occlusal disharmony sometimes causes indefinite complaint syndromes, which may be associated with astrocytic hypertrophy and the reduction of numbers of neuronal somata and their dendritic spines in the hippocampus. Microglia monitors the condition...

Reactive oxygen species, including superoxide, generally are considered neurotoxic molecules whose effects can be alleviated by antioxidants. Different from this view, we show that scavenging of superoxide with an antioxidant enzyme is associated with deficits in hippocampal long-term potentiation (LTP), a putative neural substrate of memory, and hippocampal-mediated memory function. Using tran...

This paper describes a modeling-control paradigm to control the hippocampal output (CA1 response) for the development of hippocampal prostheses. In order to bypass a damaged hippocampal region (e.g., CA3), downstream hippocampal signal (e.g., CA1 responses) needs to be reinstated based on the upstream hippocampal signal (e.g., dentate gyrus responses) via appropriate stimulations to the downstr...

Klann, Eric. Cell-permeable scavengers of superoxide prevent shown that extracellular application of superoxide dismulong-term potentiation in hippocampal area CA1. J. Neurophysiol. tase (SOD) and catalase, enzymes that catalyze the re80: 452–457, 1998. Long-term potentiation (LTP) in hippocampal moval of superoxide and hydrogen peroxide, respectively, area CA1 is generally dependent on N-methy...

Objective(s):The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: T...