Activation of alpha 1-adrenergic receptors in BC3H-1 muscle cells has been shown previously to mobilize intracellular Ca2+, which can be monitored as enhanced 45Ca2+ unidirectional efflux. We report here that histamine also stimulates 45Ca2+ efflux in these cells (Kact = 5.50 microM, nH = 0.94 +/- 0.04), reflecting mobilization of intracellular Ca2+ from a source similar to that accessed by alp...

The role of the basolateral amygdala (BLA) in the consolidation of aversive memory is well established. Here we investigate the involvement of the histaminergic system in BLA on this variable. Rats were chronically implanted with bilateral cannulae in the BLA and after recovery were trained in a one-trial step-down inhibitory avoidance task. Immediately after training histaminergic compounds ei...

The role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of famotidine as histamine H2 -receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male Ross broiler chicks reared in groups of four weeks, 16 samples (control and test ) were then inject...

Champion, Hunter C., Trinity J. Bivalacqua, David G. Lambert, Rasheed A. Abassi, and Philip J. Kadowitz. Analysis of vasoconstrictor responses to histamine in the hindlimb vascular bed of the rabbit. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1179–R1187, 1999.—Hemodynamic responses to histamine were investigated in the anesthetized rabbit. Intravenous injections of histami...

The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist...

Purpose. It has been confirmed that inflammatory cytokines are involved in the progression of pterygium. Histamine can enhance proliferation and migration of many cells. Therefore, we intend to investigate the proliferative and migratory effects of histamine on primary culture of human pterygium fibroblasts (HPFs). Methods. Pterygium and conjunctiva samples were obtained from surgery, and tolui...

Thiazolidinediones are commonly used anti-diabetic drugs. Owing to the anti-inflammatory action of TZDs as a result of there action on the PPAR gamma receptor and a proposed action on the prostaglandins, these drugs can be tried in the acute exacerbations of COPD that are also commonly found among diabetic patients. An experimental study of one week was carried out at animal house of Army Medic...

background: high levels of histamine and dopamine are found in the hippocampus. furthermore, interaction between histamine and dopaminergic d2 receptors has been demonstrated in the modulation of some behaviors. in the present study, interaction between histamine and dopaminergic d2 receptor in the dorsal hippocampus in the anxiety behavior has been investigated. methods: in this experimental s...

The superior vestibular nucleus (SVN), which holds a key position in vestibulo-ocular reflexes and nystagmus, receives direct hypothalamic histaminergic innervations. By using rat brainstem slice preparations and extracellular unitary recordings, we investigated the effect of histamine on SVN neurons and the underlying receptor mechanisms. Bath application of histamine evoked an excitatory resp...

Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 - 100 microg/site) led to increased plasma exudation in the skin. The LPA-...