DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders. The first histone deacetylase inhibitor, vorinostat, has been licensed for cutaneous T cell lymphoma treatment. More than 11 new epigenetic agents are in various s...

Many bony features of the face develop from endochondral ossification preexisting collagen-rich cartilage structures. The proper development these structures is essential to morphological formation face. developmental programs governing pre-bone facial cartilages are sensitive chemical compounds that disturb histone acetylation patterns and chromatin structure. We have taken advantage this fact...