INTRODUCTION Celiac disease (CD) is a permanent intolerance to gluten that occurs in genetically predisposed individuals and leads to small intestinal mucosa damage. According to ESPGHAN guidelines from 2012, CD can be diagnosed in a patient with characteristic clinical symptoms, in whom, anti-tissue transglutaminase antibodies (> 10 times the upper limit) are found, endomysial antibodies (EMA)...

BACKGROUND Celiac disease (CD) has a strong genetic component mainly due to HLA DQ2/DQ8 encoding genes. However, a minority of CD patients are DQ2/DQ8-negative. To address this issue, we retrospectively characterized HLA haplotypes in 5,535 subjects at risk of CD (either relatives of CD patients or subjects with CD-like symptoms) referred to our center during a 10-year period. METHODS We iden...

Gluten sensitive enteropathy also known as Celiac disease, an autoimmune disorder which occurs in the presence of HLA DQ2 & DQ8 gene genetically susceptible individuals. Homoeopathy can direct treatment constitutionally and therapeutically. Gliadin a derivative gluten is modified by TTG seen antigen to Antigen presenting cells. The lead failure thrive.

BACKGROUND AND AIMS Coeliac disease (CD) is an enteropathic disorder characterised by a strong association with major histocompatibility complex (MHC) heterodimer HLA-DQ2. It has been suggested that other HLA class I genes in combination with DQ may also contribute to CD susceptibility. The aim of this study was to investigate whether other candidate genes modify the risk of developing differen...

Islet autoimmunity is initiated in infancy, and primary prevention trials require children at high genetic risk to be identified before autoantibodies appear. To inform screening strategies, we evaluated risks of autoimmunity and diabetes associated with HLA DR3-DQ2/DR4-DQ8 in U.K. families. Extended HLA haplotypes were determined in 2,134 siblings from the Bart's-Oxford Study followed to a med...

background: hepatitis b is an important infectious disease.  since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of iran.  however, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination. objectives: to investigate distribution of hla class-i and class-ii antigens in healt...

The HLA (Human Leucocyte Antigens) class I and class II polymorphism in a sample population of 250 Vojvodinians using standard microlymphocytotoxicity test was investigated. The antigens with the highest frequencies were: HLA-A2 (50.4%), A1 (24.1%) and A3 (22.7%); B35 (22.7%), B51(5) (16.9%) and B18 (15.6%); DR11 (5) (34.5%), DR7 (20.0%) and DR3 (19.3%); DQ1 (44.8%), DQ7 (3) (30.9%) and DQ2 (13...

selective iga deficiency (igad) (serum iga concentration of pcr was used to type hla b, dr, and dq alleles in 29 iranian individuals with igad and 299 swedish individuals with igad. the results indicate a strong association with the hla b14, dr1 alleles in iranian subjects and hla b8, b12, b13, b14, b40, dr1, dr3, dr7, dq2 and dq5 alleles in swedish subjects. differences in hla association of i...

BACKGROUND Patients with type 1 diabetes mellitus (T1DM) have an increased risk of celiac disease (CD). Both diseases have a common genetic susceptibility locus in the human leukocyte antigen (HLA) class II alleles. Testing for tissue transglutaminase antibodies (anti-tTG) is highly accurate for a CD diagnosis. OBJECTIVE To determine the frequency of HLA-DQB1*0201/02 and DQB1*0302 alleles and...

An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying receptor signatures associated with disease challenging due to the overall complexity antigens polymorphic HLA allotypes. In celiac disease, epitopes are well characterised specific HLA-DQ2-restricted T-cell has been explored in depth. By inves...