Plasma homocysteine is cross-sectionally associated with blood pressure in large, community-based studies. It is unknown whether elevated plasma homocysteine predicts hypertension incidence. We investigated the relations of baseline plasma total homocysteine levels to hypertension incidence and blood pressure tracking in 2104 Framingham Heart Study participants (mean age, 57 years; 58% women), ...

background: polycystic ovarian syndrome (pcos) represent one of the common endocrine disorders which influence around 8% of reproductive women whom usually suffering from obesity and increase cardiovascular risk. serum homocysteine levels are associated with bad impact on endothelial functions and considered as an independent risk factor for cardiovascular disease. objective: the aim was to stu...

BACKGROUND Lead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors. OBJECTIVES We examined the longitudinal association of recent and cumulative Pb exposure with hom...

Available evidence suggests that both homocysteine and blood pressure variability (BPV) are closely correlated with cardio-cerebrovascular disease. However, no previous study has addressed the correlation between homocysteine levels and 24-h ambulatory BPV. The aim of this study was to investigate the relationship between serum homocysteine levels and 24-h ambulatory BPV in Chinese hypertensive...

Introduction: Various research works have reported elevated serum homocysteine levels with the use of antiepileptic drugs. This may lead to an increased risk atherosclerosis, a higher seizure frequency and also cause cognitive decline. Methods: Twenty five children (Two 12 years) on valproate monotherapy for more than one year same number age sex-matched healthy controls were enrolled. Venous b...

INTRODUCTION. Hyperhomocysteinemia is common in patients with chronic kidney disease. There is a direct relationship between cardiovascular mortality and increase of blood homocysteine. Folic acid is used as common treatment in such patients. Folinic acid, a shortened form of folic acid, is not affected by inhibitors of dihydrofolate reductase enzyme such as methoterxate. This study was perform...

H omocysteine is a chemical in the blood. It is formed when the amino acid methionine, which is a building block of the proteins in our food and body, is naturally broken down (ie, metabolized) to be excreted in the urine (Figure). During this breakdown process, homocysteine can be recycled by our body to be reused to build other proteins. For this recycling, we need vitamins B 12 , B 6 , and f...

To the Editor: Increased plasma homocysteine is regarded as a risk factor for arterial and venous occlusive disease. Sample collection ideally requires use of cooled EDTA containers and immediate centrifugation of the blood (1). These conditions may be hard to maintain in a clinic and are not possible in the many medical practices that lack a centrifuge. We tested whether analyzing uncentrifuge...