www.sciencemag.org SCIENCE VOL 328 21 MAY 2010 943 COVER Tumor-penetrating transport of cancer drugs is activated by the peptide iRGD (multicolored ring), which binds to integrin receptors (blue and yellow) in tumor blood vessels, and is subsequently cleaved. The cleaved peptide then binds to neuropilin-1 receptors (purple), activating a transport system that carries coadministered drugs, such ...

Angelina Jolie’s announcement that she had undergone a double mastectomy to ward off potential tumors induced by her BRCA1 mutation served as what Kenneth Offit, MD, called a teachable moment. “Public figures can have seismic impacts on health communication when they speak about their own experiences,” said Offit, chief of the Clinical Genetics Service at the Memorial Sloan–Kettering Cancer Cen...

Fuel nozzle is a key part of aero-engines. Due to the particularity fuel nozzle’s working environment, high machining requirements for surface quality and geometric accuracy hole were put forward. The existing process difficult meet requirements, so new proposed, which called flexible single-pass honing. For novel honing tool with diameter less than 1 mm, laws are not very clear, studies carrie...