Here the histopathology findings of placental infarction associated with late preterm birth are reported. The subject was a male neonate delivered at 34 weeks and 5 days of gestation with a birth weight of ∼2500 g. His mother had been diagnosed with a threatened premature birth at 27 weeks of pregnancy. The size and weight of the placenta was considered appropriate for gestational age. On the c...

BACKGROUND Uterine fibroids or leiomyomas are benign tumours that develop in the uterus, a female reproductive organ. These cause severe complications in females during pregnancy. This study was conducted to see the impact of leiomyoma in pregnant females to make decision for its management in future. METHODS During one year of study, total 10,842 patients presented in CMH Lahore for antenata...

This study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 2006-2014 compared to naturally conceived pregnancies (N = 5282) after matching for maternal age an...

The placenta forms connection between growing fetus and uterine wall and is a unique, temporary, highly specialized organ required for the development of the embryo and fetus. In humans, as early as 3-4 days after fertilization trophoblas-tic cells can be identified on the outer layer of cells within the blastocyst. These precursor cells differentiate into all the other placental cell types tha...

PURPOSE To evaluate whether type and location of placenta previa affect risk of antepartum hemorrhage-related preterm delivery. METHODS We retrospectively studied 162 women with singleton pregnancies presenting placenta previa. Through observation using transvaginal ultrasound the women were categorized into complete or incomplete placenta previa, and then assigned to anterior and posterior g...

The placenta is essential for the success of therian mammalian reproduction. Intense selective pressure has shaped changes in placental anatomy and function during mammalian cladogenesis. Here we challenge the view that the hemochorial placenta is a derived feature in haplorhine primates. Using phylogenetic and statistical analyses of molecular and morphological data, we demonstrate that the an...

During pregnancy, the placenta undergoes a natural aging process, which is considered normal. However, it has been hypothesized that an abnormally accelerated and premature of may contribute to placenta-related health issues. Placental senescence linked several obstetric complications, including abnormal fetal growth, preeclampsia, preterm birth, stillbirth, with stillbirth being most challengi...

Fetal drug exposure is determined by the type and concentration of placental transporters, and their regulation is central to the development of new treatments and delivery strategies for pregnant women and their fetuses. We tested the expression of several clinically important transporters in the human placenta associated with various pregnancy conditions (i.e., labor, preeclampsia, and preter...

Preterm birth remains the leading cause of neonatal mortality and morbidity worldwide. There are currently few effective therapies and therefore an urgent need for novel treatments. Although there is much focus on trying to alter gestation of delivery, the primary aim of preterm birth prevention therapies should be to reduce prematurity related mortality and morbidity. Given the link between in...