This work demonstrates the fabrication of microfluidic paper-based analytical devices (μPADs) suitable for the analysis of sub-microliter sample volumes. The wax-printing approach widely used for the patterning of paper substrates has been adapted to obtain high-resolution microfluidic structures patterned in filter paper. This has been achieved by replacing the hot plate heating method convent...

In the present study, a finite volume method is employed to model the advection-diffusion phenomenon during a pure substance melting process. The exercise is limited to a benchmark problem consisting of the 2D melting from a vertical wall of a PCM driven by natural convection in the melt. Numerical results, mainly the temporal evolution of average Nusselt number at the hot wall and the average ...

This thesis proposes a way to simulate the interaction of fluids and solids based on the Smoothed Particle Hydrodynamics method. The interaction is facilitated by not only representing fluids with particles, but solid objects as well. Linear elastic forces are computed between neighbouring particles to create deformable objects. The animation of fully rigid objects is made possible by introduci...

A model was developed taking into consideration the heat and mass transfer processes in liquidsprayed fluidized beds. Such fluidized beds (FB) are used for granulation, coating and agglomeration. Conclusions are drawn on the relevance of particle dispersion, spraying and drying to temperature and concentrations distributions. In extension, the model was coupled with a population balance model t...

Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism nanoparticulate approach, modifying the release, binders, permeation enhancers, transfection agents etc. alone or combination polymers increasingly being hot melt extrusion (HME) technology preparation controlled release formulation...

Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...