HOXA10 and HOXA11 are homeobox genes that function as transcription factors essential to embryonic development. We have recently described a role for each of these two genes in regulating endometrial development in the adult during the course of a menstrual cycle. Both Hoxa10 and Hoxa11 are essential for implantation in the mouse and appear to play a similar role in women. To investigate the ro...

Prevalensi prolaps uteri tergolong tinggi dan meningkat sejalan dengan paritas. Angka tersebut akanterus karena usia harapan hidup perempuan juga meningkat. Hal berdampak padakualitas perempuan. Faktor risiko klinis yang saling terkait proses perkembangan adalahkehamilan, persalinan, berat lahir bayi, obesitas, menopause, kebiasaan mengangkat benda berat, batuklama, konstipasi. Kerusakan penyok...

We show here that expression of Hoxa10 in the presomitic mesoderm is sufficient to confer a Hox group 10 patterning program to the somite, producing vertebrae without ribs, an effect not achieved when Hoxa10 is expressed in the somites. In addition, Hox group 11-dependent vertebral sacralization requires Hoxa11 expression in the presomitic mesoderm, while their caudal differentiation requires t...

background: hoxa11 and leukemia inhibitory factor (lif) and basic transcriptional element binding protein1 (bteb1) are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. in this case-control study, the expression pattern of these mrna was evaluated in patients with endometriosis at the time of implantatio...

Abstract: In addition to its many functions, the placenta is characterized by intensity and characteristics of hormonal functions. It has been reported that development vascularization with normal fetal growth regulated factors such as factors, transcriptional homeobox proteins. This study was conducted determine distribution possible physiological roles HOXA11 HLX in uterus pregnant cows. this...

Hypodactyly (Hoxa13Hd) mice have a small deletion within the coding sequence of Hoxa13 and a limb phenotype that is more severe than that of mice with an engineered null allele of Hoxa13. We used whole-mount in situ hybridization, Nile blue sulfate staining and genetic crosses to determine the basis for the phenotypic differences between these two mutants. Expression of Hoxd13 was unaffected in...

Hox genes are well known for their key contribution to the establishment of the body architecture. This function relies on both local and long-range cis-regulatory elements that generate nested expression patterns of the various Hox genes along the anterior–posterior axis of the developing embryo. Interestingly, analyses of expression patterns in different species suggested that modulation of t...

Mutations in the 5' or posterior murine Hox genes (paralogous groups 9-13) markedly affect the formation of the stylopod, zeugopod and autopod of both forelimbs and hindlimbs. Targeted disruption of Hoxa11 and Hoxd11 or Hoxa10, Hoxc10 and Hoxd10 result in gross mispatterning of the radius and ulna or the femur, respectively. Similarly, in mice with disruptions of both Hoxa13 and Hoxd13, develop...

Epithelial-mesenchymal interactions play a crucial role in the correct patterning of the mammalian female reproductive tract (FRT). Three members of the Wnt family of growth factors are expressed at high levels in the developing FRT in the mouse embryo. The expression of Wnt genes is maintained in the adult FRT, although levels fluctuate during estrous. Wnt4 is required for Müllerian duct initi...

The mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phenotypes which are difficult to interpret by molecular analysis. For example, mice individually mut...