ation (Nickoloff and Reynolds, 1990; Nickoloff, 1992) The induction of recombination by transcription activand gene targeting (Thyagarajan et al., 1995) in mamation has been documented in prokaryotes and eukarymalian cells, and site-specific recombination in the otes. Unwinding of the DNA duplex, disruption of immunoglobulin genes (Blackwell et al., 1986; Leung and chromatin structure or change...

Diverse and precise control is essential for eukaryotic gene expression. This is accomplished through the recruitment of a myriad of proteins to a nascent messenger RNA (mRNA) to mediate modifications, such as capping, splicing, 3'-end processing, and export. Despite being important for every cell, however, the mechanism by which the formation of diverse messenger ribonucleoprotein (mRNP) parti...

Several aspects of eukaryotic mRNA processing are linked to transcription. In Saccharomyces cerevisiae, overexpression of the mRNA export factor Sub2p suppresses the growth defect of hpr1 null cells, yet the protein Hpr1p and the associated THO protein complex are implicated in transcriptional elongation. Indeed, we find that a pool of heat shock HSP104 transcripts are 3'-end truncated in THO c...