The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 μM. HUHS1015 induced both necrosis and apoptosis of MSTO-211H and NCI-H2052 cells. HUHS1015 upregulated expressio...

Zusammenfassung Die große Bedeutung der Informationstechnologie für die Wissenschaftsdisziplinen und zentralen Infrastruktureinrichtungen Hochschulen steht heutzutage außer Frage. Der Beitrag liefert einen historischen Überblick über Einführung Weiterentwicklung IT in deutschen von den 1950er-Jahren bis heute, wobei Fokus auf Bibliotheken Rechenzentren liegt. Es zeigt sich, dass verschiedenen P...

BH3-only members of the Bcl-2 intracellular protein family, which include Bim, Bmf, Bik, Bad, Bid, Puma, Noxa and Hrk, mediate many developmentally programmed and induced cytotoxic signals. They have key roles in development, tissue homeostasis, immunity and tumor suppression, and compounds mimicking them are promising anti-cancer agents. Their activity is normally constrained by transcriptiona...

Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that TFD caused not only induction but also phosphorylation of BIM(EL). Mitochondrially localized J...

KiG No. 22, Vol. 1 3, 201 4 12. Publish a contest in accordance with the Regulations on CCS Awards. 13. Organize workshop of the ICA Commission on Map Projections in October 2014. The president presented the financial plan for 2014, according to which expected income and expenses amount to 200.000,00 HRK. After a brief discussion, the financial plan for 2014 was accepted unanimously. After intr...

In spinach (Spinacea oleracea L.) leaf extracts, three protein kinases (PKI, PKII and PKIII) were identified each of which phosphorylated spinach nitrate reductase on serine-543, and inactivated the enzyme in the presence of nitrate reductase inhibitor, 14-3-3. PKIII was also very active in phosphorylating and inactivating Arabidopsis (Landsberg erecta) 3-hydroxy-3-methylglutaryl-coenzyme A red...