BACKGROUND Allogeneic hematopoietic stem cell transplantation (HSCT) is the preferred curative therapy for children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). We evaluated the treatment outcomes of children with Ph+ ALL who underwent allogeneic HSCT. METHODS Fifteen children diagnosed with Ph+ ALL in Asan Medical Center Children's Hospital between 1998 and...

Our inability to purify hematopoietic stem cells (HSCs) precludes direct study of many aspects of their behavior in the clinical hematopoietic stem cell transplantation (HSCT) setting. We indirectly assessed stem/progenitor cell behavior in the first year after HSCT by examining changes in neutrophil telomere length, X-inactivation ratios, and cycling of marrow progenitors in 25 fully engrafted...

Abstract Background This prospective longitudinal study examined and compared two measures (prospective retrospective ones) of post-traumatic growth (PTG) following Hematopoietic Stem-Cell Transplantation (HSCT) their respective relationships with mental health psychological disposition. We also tested the hypothesis that unwillingness to be in contact distressing thoughts feelings—i.e. experie...

Previous studies have shown that hematopoietic stem cell transplantation (HSCT) may result in growth impairment. The purpose of this study was to evaluate the growth during 5 yr after HSCT and to determine factors that influence final adult height (FAH). We retrospectively reviewed the medical records of acute myeloid leukemia (AML) patients who received HSCT. Among a total of 37 eligible patie...

After Yttrium (Y90) Ibritumomab tiuxetan (Zevalin) and Iodine (131I) tositumomab (Bexxar) were approved by the FDA, the improved response of B-cell NHL to this novel RIT makes it a promising alternative to more aggressive treatment like HSCT. In this study, we describe the experience of a single community-based cancer center with RIT and HSCT in patients with B-cell NHL in terms of response, su...

BACKGROUND Survival after allogeneic haemopoietic stem cell transplantation (allo-HSCT) has improved because of advancements in allo-HSCT. Allo-HSCT has been performed in Australia since the late 1970s. However, there are few published data about health problems of allo-HSCT survivors in Australia. AIMS Identify health issues in long-term survivors of allo-HSCT in an Australian centre to mana...

BACKGROUND The occurrence of diffuse alveolar hemorrhage (DAH) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare but severe. There are few reports that have examined the correlation between pre-HSCT chemotherapeutic exposure and DAH. OBJECTIVES We examine the role of pre-HSCT chemotherapeutic exposure, conditioning regimens, pre-HSCT comorbidities and transplant-rel...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Systemic sclerosis (SSc) can cause cardiac complications as a result multi-organ fibrosis. The study left atrial (LA) mechanics offer insights into the pathophysiology involvement in SSc. LA strain measured by speckle-tracking echocardiography (STE) has been shown to be sensitive marker function. impact disease modify...

2. Narrative: In the Phase I grant application, we hypothesized that the hematopoietic stem cell therapy (HSCT) could prevent/mitigate astronauts' various disorders in space, enabling them to “go anywhere at anytime” and come back to earth just as they left. Amongst the disorders in space, which include hematological/cardiac abnormalities, bone and muscle losses, immunodeficiency, neurological ...

hematopoietic stem cell transplantation (hsct) has been practiced for more than 30 years. hematological malignanciesare the main indications for this treatment. however, its indications in adults are different from children.advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of hsct in children. multi-center c...