Introduction. There are problems with the existing definition of hypoactive sexual desire disorder (HSDD) in that desire for sex and sexual fantasy are not a universal experience. Aims. To explore: (i) women’s motivations to engage in sexual activity; (ii) frequency and predictors of sexual fantasies; (iii) sexual arousal; (iv) recognition of sexual arousal; and (v) association between relation...

INTRODUCTION Psychopathological origins of personally distressing, hypoactive sexual desire disorder (HSDD) in women are unknown, but are generally attributed to an inhibitory neural regulator, serotonin (5-HT). Flibanserin, a 5-HT(1A) agonist and 5-HT(2A) antagonist, shows promise as a treatment for HSDD. AIM To test the hypothesis that female marmoset sexual behavior is enhanced by flibanse...

OBJECTIVE This study aimed to assess the efficacy and safety of flibanserin, a serotonin receptor 1A agonist/serotonin receptor 2A antagonist, in postmenopausal women with hypoactive sexual desire disorder (HSDD). METHODS Naturally postmenopausal women with HSDD received flibanserin 100 mg once daily at bedtime (n = 468) or placebo (n = 481) for 24 weeks. Co-primary endpoints were changes fro...

ISSUE Hypoactive sexual desire disorder (HSDD) is hypothesized to be a disorder of the brain's reward circuitry. Neurotransmitters in reward circuits are thus therapeutic targets for improving sexual desire. Novel treatment strategies are to enhance dopamine (DA) actions, reduce serotonin (5-HT) actions, or both.

The article deals with the possible methodology of processing of data and information for the search of prediction of heat supply daily diagram (HSDD). The methodology includes technical analyses regression analysis, dynamic models, fuzzy logic, artificial neural networks, genetic algorithms, chaos analysis, hybrid models, dynamical simulations and other methods. The process of decision making ...

Abstract Introduction The Decreased Sexual Desire Screener (DSDS) is a five-item self-report questionnaire used to assist clinicians in diagnosis of generalized acquired Hypoactive Disorder (HSDD). While the first four items this assess whether woman has decreased sexual desire that causing her distress, fifth item assists identifying possible medical and psychological factors could confound HS...

INTRODUCTION Although approximately 40% of women report female sexual problems--and particularly sexual desire disorders, there are numerous practical, professional, and personal barriers to their diagnosis and management by treating clinicians. AIM To identify practice patterns, perceptions, and barriers to the diagnosis and management of female sexual problems among U.S. practicing primary ...

Abstract Introduction Flibanserin is approved in the United States (US) for premenopausal women and Canada pre naturally postmenopausal women, ≤60 years of age, to treat acquired, generalized hypoactive sexual desire disorder (HSDD). Clinical trials suggest that flibanserin's safety profile similar among pre-and women. During a Phase 3 study, most frequently reported adverse events (AEs) were d...

Abstract Introduction The “Dual control model” of sexual response postulates that desire and associated behaviors depend on the balance between excitation inhibition. These aspects have not been evaluated in women with dysfunction (FSD). Objectives aim our study was to explore psychosexual correlates inhibition FSD, according their menopausal state. We also aimed at performing a pre-post analys...

Human asexuality is defined as a lack of sexual attraction, and research suggests that it may be best conceptualized as a sexual orientation. Sexual fantasies are thought to be universally experienced and are often understood to represent true sexual desire more accurately than sexual behaviour. We investigated the relationship between asexuality, masturbation and sexual fantasy as part of a la...