Background Although ovarian tissue cryopreservation and transplantation is used for fertility preservation in patient undergoing cytotoxic treatments but obtaining good quality oocyte is still a debate. Xenotransplantation has been introduced as a reliable technique for better understanding of the transplantation conditions, but to achieve healthy embryos, the quality of obtained oocytes need t...

bleomycin (blm)as an anti-cancer agent causes tissue toxicities through dna damaging and cell deaths. the aim of this study was to investigate the effects of thymol against genotoxicity and anti-proliferation induced by blm in normal human lymphocytes and ovarian cancer cells.peripheral blood samples were collected from human volunteers and were incubated with thymolat different concentrations ...

The objective of this study was to explore the feasibility and methods of screening the residual normal ovarian tissue adjacent to orthotopic ovarian carcinomas in nude mice. Human epithelial ovarian cancer cells (OVCAR3) were subcutaneously implanted for a tumor source and ovarian orthotopic transplantation. The cancer tissue, proximal paraneoplastic tissue, middle paraneoplastic tissue, remot...

objective: this study was designed to evaluate the effects of vitrification and in vitro culture of human ovarian tissue on the expression of oocytic and follicular cell-related genes. materials and methods: in this comparative study, ovarian tissue samples were obtained from eight transsexual women. samples were cut into small fragments and were then assigned to vitrified and non-vitrified gro...

BACKGROUND Sphingosine-1 receptor 1 (S1P1) plays a major role in regulating lymphocyte egress from peripheral lymph tissue. Lymphocyte trafficking is potentially a critical response to tumors and to tumor vaccines. Also, the receptor has been shown to influence metastasis. However, there is little information on its expression in the aged ovary or ovarian tumors. As a basis for further studies ...

The ultimate aim of ovarian cryopreservation research is naturally to increase the effectiveness of this fertility preservation procedure in female cancer victims and much of this research on whole ovary cryopreservation, ovarian cortex cryopreservation and transplantation has been performed in animal models. However, ovarian cryopreservation could also be used in the future in programs with th...

PURPOSE The tetraspan protein epithelial membrane protein-2 (EMP2) has been shown to regulate the surface display and signaling from select integrin pairs, and it was recently identified as a prognostic biomarker in human endometrial cancer. In this study, we assessed the role of EMP2 in human ovarian cancer. EXPERIMENTAL DESIGN We examined the expression of EMP2 within a population of women ...