نتایج جستجو برای: human platelet antigens hpa
تعداد نتایج: 1779969 فیلتر نتایج به سال:
Prediction of IVIG treatment efficiency in fetal/neonatal alloimmune thrombocytopenia Fetal/neonatal alloimmune thrombocytopenia resulting from specific maternal immunization against human platelet antigens (HPAs) is the most frequent cause of severe isolated thrombocytopenia (platelet counts ,50 3 10 9 /L) in maternity wards, and its most destructive consequence is intracranial hemorrhage (20%...
To cite: Williams T, Wilkinson AG, Kandasamy J, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014209130 DESCRIPTION A 27-year-old woman was referred at 37 weeks’ gestation for confirmation of malpresentation. Incidental hydrocephalus was found on ultrasound. Fetal MRI confirmed dilation of the lateral and third ventricles and an extensive mixed signal in...
BACKGROUND/AIM A low platelet count is one of the most sensitive tests for cirrhosis detection in patients with hepatitis C virus (HCV) infection. We evaluated whether the human platelet antigen (HPA) genotype could predict platelet count in HCV-positive patients. MATERIALS AND METHODS We genotyped the HPA 1, 2, 3, 5 and 15 polymorphisms in consecutive patients with HCV infection. RESULTS O...
Human platelet alloantigens (HPAs) reside on functionally important platelet membrane glycoproteins and are caused by single nucleotide polymorphisms in the genes that encode them. Antibodies that form against HPAs are responsible for several clinically important alloimmune bleeding disorders, including fetal and neonatal alloimmune thrombocytopenia and posttransfusion purpura. The HPA-1a/HPA-1...
High-density protein microarrays of recombinant human protein fragments, representing 12,412 unique Ensembl Gene IDs, have here been produced and explored. These protein microarrays were used to analyse antibody off-target interactions, as well as for profiling the human autoantibody repertoire in plasma against the antigens represented by the protein fragments. Affinity-purified polyclonal ant...
Allelic and genotypic frequencies of platelet glycoprotein polymorphisms in a Portuguese population.
INTRODUCTION AND OBJECTIVES We studied genotypic and allelic frequencies of polymorphisms that can affect platelet function, namely the Kozak, VNTR and HPA-2 polymorphisms of glycoprotein Ibα, the Pl(A) polymorphism of glycoprotein IIIa and the C807T polymorphism of glycoprotein Ia, in a Portuguese population composed of 227 donors. METHODS PCR-RFLP was used to assess the Kozak, HPA-2, Pl(A) ...
Immunoglobulin G (IgG) formed during pregnancy against human platelet antigens (HPAs) of the fetus mediates fetal or neonatal alloimmune thrombocytopenia (FNAIT). Because antibody titer or isotype does not strictly correlate with disease severity, we investigated by mass spectrometry variations in the glycosylation at Asn297 in the IgG Fc because the composition of this glycan can be highly var...
Immunization against the human platelet antigen (HPA)-1 alloantigen is the most common cause of severe fetal and neonatal thrombocytopenia. Fetal therapy has substantial risks and its indications need better definition. Of 24,417 consecutive pregnant women, 618 (2.5%) were HPA-1a negative of whom 385 entered an observational study. All were HLA-DRB3*0101 genotyped and screened for anti-HPA-1a. ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید