BACKGROUND Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair. EXPERIMENT AND FINDINGS We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6 h, a platelet concentrate was injected per...

The use of biologic augmentation following microfracture for symptomatic cartilage defects the knee with osseous involvement shows encouraging results. Bone marrow aspirate concentrate provides growth factors to injury site, such as vascular endothelial factor, platelet-derived transforming factor-βa, and bone morphogenetic proteins in addition mesenchymal stem cells present concentrate. Cellul...

PURPOSE To describe the long-term clinical course in children with a traumatic macular hole after vitrectomy with platelet concentrate. DESIGN Interventional case series. METHODS Four pediatric patients with a mean age of 13.2 years (range, 10-15 years) underwent pars plana vitrectomy with platelet concentrate, internal limiting membrane peeling, and SF6 gas tamponade for stage 3 traumatic ...

Introduction:The use of autogenous concentrated blood products, particularly platelets, has become increasingly widespread as an effective clinical tool to accelerate wound healing. Upon activation, platelets release cytokines (i.e PDGF and TGFß1) and platelet membrane particles (PMP). Major obstacles to understanding the mechanisms of these clinical successes lie in the many different clinical...

Platelet-rich fibrin (PRF) is a fibrin meshwork, in which platelet cytokines, growth factors, and cells are entrapped and discharged after a period and can serve as a resorbable film. PRF is the next generation of platelet concentrates equipped to improve arrangement without biochemical blood handling; PRF is an evolution of the fibrin adhesive, which is widely used in the oral surgery. The gui...

l P ( p u d F m S P r B t e l ( b P W i p p a latelet-rich plasma (PRP) is an autologous concentraion of human platelets in a small volume of plasma. herefore, the term PRP is preferred to autologous latelet gel, plasma-rich growth factors (PRGFs), or a ere autologous platelet concentrate. Because it is a oncentration of platelets, it is also a concentration of he 7 fundamental protein growth f...

BACKGROUND Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a rea...

Six patients received platelet concentrate transfusions from their HLA-identical siblings. Platelet concentrates were administered either fresh, or after being frozen in 10% dimethylsulfoxide, at a slow controlled rate (1 degree C/min) or rapidly (approximately 8 degrees C/min) in the vapor-phase of a liquid nitrogen refrigerator. The median freeze-thaw loss was 13.5%. The mean 1-hr and 20-hr c...