BACKGROUND Vitiligo is one of many diseases that can be found with diabetes mellitus. Diabetic patients have a high incidence of vitiligo compared to the general population. This study assesses prevalence of vitiligo in type 2 diabetic patients in Iran. METHODS One thousand one hundred type 2 diabetic patients and 1100 healthy adults were recruited in this cross-sectional study. Patients were...

Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals w...

In vitiligo, autoreactive CD8+T cell is established as the main culprit considering their pathogenic role in mediating epidermal melanocyte-specific destruction. Macrophage migration inhibitory factor (MIF) a pleiotropic molecular that plays central various immune processes including activation and proliferation of T cells. But whether MIF intertwined vitiligo development progression its implic...

The aetiopathogenesis of vitiligo has not been fully understood. To investigate the role of oxidative stress in pathogenesis of vitiligo, we examined the blood level of antioxidants and malondialdehyde in 40 patients with generalized vitiligo and 40 healthy volunteers belonging to same age group. Our results revealed that the level of malondialdehyde was significantly raised while those of vita...

Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as abnormal immune responses have frequently been observed in vitiligo patients. Moreover, vitiligo patients show higher lesion levels of TNF-α. Genetic polymorphisms in the promoter region of TNF-α are involved in the regulat...

BACKGROUND Recent clinical and animal experimental studies postulate that the pathogenetic mechanisms of vitiligo could be of systemic origin as vitiligo is associated with ocular and auditory abnormalities as well as other autoimmune disorders.Hence, we studied genetic factors, systemic associations, ocular and auditory abnormalities of vitiligo. METHODS The study group included 150 new case...

Vitiligo is a depigmentation disorder; Reactive Oxygen Species (ROS) plays a major role in the development of depigmentation. Monoamine oxidase-A(MAO-A) enzyme is one of the reasons in producing ROS by metabolizing norepinephrine which found to be high level in vitiligo patients. Inhibiting MAO-A enzyme prevents further depigmentation. Clinical studies proved that the isoquinoline alkaloids hav...

Accumulation of hydrogen peroxide (H(2)O(2)) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping...

Background Vitiligo is an acquired hypopigmentary disorder. The prevalence of vitiligo is 0.1-2% worldwide. Numerous autoimmune diseases are associated with vitiligo, including autoimmune thyroid diseases. The prevalence of thyroid abnormalities is up to 34% in vitiligo patients depending on ethnicities. Objective This study aims to investigate thyroid abnormalities in Thai patients with viti...

Vitiligo is an autoimmune disease with a strong genetic component, characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Genetic factors are known to play key roles in vitiligo through discoveries in association studies and family studies. Previously, vitiligo susceptibility genes were mainly revealed through linkage analysis and candidate gene studies. Recent...