This essay introduces papers delivered at a conference on Lucy Hutchinson, Nottingham, June 2022. While Hutchinson’s ‘Elegies’ and Order Disorder are discussed, the majority focus Memoirs of Life Colonel which manuscript was freshly display in special gallery Nottingham Castle. I discuss interdisciplinary range papers, from local military history to European intellectual history, gender theory ...

1. Society of Arts. 29 May 1844.-W. H. Bodkin, Esq., M.P., V.P., in the chair. Lancet, 1844, i: 390-391 (15 June). Notes: "The Secretary read a paper by Mr. Hutchinson on his Pneumatic Apparatus for Valuing the Respiratory Powers, which was illustrated by about twenty large diagrams and tables. The apparatus was also placed on the table." At first sight it would appear that Hutchinson himself w...

To the present generation of doctors the name of Jonathan Hutchinson is associated with certain signs of syphilis, but there was "hardly any branch of medicine to which he did not make any contribution. For more than 20 years he was surgeon to London Hospital, and he was also on the staff of hospitals for chest, skin and eye diseases. It was an extraordinarily prolific period during which he ma...

This article is concerned with Monte-Carlo methods for the estimation of the trace of an implicitly given matrix A whose information is only available through matrix-vector products. Such a method approximates the trace by an average of N expressions of the form w(Aw), with random vectors w drawn from an appropriate distribution. We prove, discuss and experiment with bounds on the number of rea...

A de novo G608G mutation in LMNA gene leads to Hutchinson-Gilford progeria syndrome. Mice lacking the prelamin A-processing metalloprotease, Zmpste24, recapitulate many of the progeroid features of Hutchinson-Gilford progeria syndrome. Here we show that A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degr...