The Hodgkin-Huxley model is the first successful mathematical model for explaining the initiation and propagation of an action potential in a neuron cell. In this paper we reinvestigated the Hodgkin-Huxley model through computer simulation and determined the threshold potentials by applying different types of stimulating input signals. To implement the work, a computer programme of the Hodgkin-...

Andrew Fielding Huxley, OM 1983; Kt 1974; FRS 1955; PRS 1980–1985, MA, Hon. ScD Cantab. Physiologist and Biophysicist. Born Hampstead, London, 22 November 1917. Demonstrator, 1946–50, Assistant Director of Research, 1951–59, and Reader in Experimental Biophysics, 1959–60, Physiological Laboratory, Cambridge; Director of Studies, Trinity College, Cambridge, 1952–60; Jodrell Professor 1960–69, Ro...

I. Refinements on the Hodgkin-Huxley Model The years since Hodgkin’s and Huxley’s pioneering work have produced a number of derivative Hodgkin-Huxley-like models. Recall that Hodgkin and Huxley developed their model from data measured in the giant axon of the squid. Therefore the original model only had voltagedependent channel models for a Na channel and a K channel. There are in addition to t...

The relationship between mechanical and metabolic behaviour in the widely used Hill muscle-tendon complex (MTC) model is not straightforward, whereas this is an integral part of the Huxley model. In this study, we assessed to what extent Huxley- and Hill-type MTC models yield adequate predictions of mechanical muscle behaviour during stretch-shortening cycles (SSCs). In fully anaesthetized male...

The Hodgkin and Huxley equations model action potentials in squid giant axons. Variants of these equations are used in most models for electrical activity of excitable membranes. Computational tools based upon the theory of nonlinear dynamical systems are used here to illustrate how the dynamical behavior of the Hodgkin Huxley model changes as functions of two of the system parameters.

The original Hodgkin-Huxley model describes action potential generation in the squid giant axon and is a paradigm for conductance-based, excitable biological systems. Motivated by the recent theoretical work of Qiudong Wang and Lai-Sang Young, this paper examines the response of the Hodgkin-Huxley equations to low-frequency periodic pulsatile forcing. It is shown that 1. The pulse-driven Hodgki...