The sine qua non of malignancy is the ability of tumor cells to migrate and invade surrounding tissue. There are many substances that have been described that enhance cell motility and hyaluronic acid is prominent among these. Hyaluronic acid is a high molecular weight alternating disaccharide polymer found in abundance in extracellular matrices whenever rapid cell proliferation or tissue regen...

Within the last 13 years hyaluronic acid has been isolated from a variety of sources (1): umbilical cord, vitreous humor, synovial fluid, tumors, and hemolytic streptococci. These mucopolysaccharides all have essentially the same chemical composition, equimolecular portions of acetylglucosamine and glucuronic acid, but vary greatly in viscosity. Hyaluronic acid was first isolated by Meyer and P...

A characteristic property of synovial fluids is the formation of a mucin clot when a weak acid is added. The physical character of the clot may be of some aid in the diagnosis of rheumatoid arthritis (Ropes, Bennett, Cobb, Jacox & Jesser, 1957; Ropes & Bauer, 1953). The clot has also been used as a preliminary step in the isolation of hyaluronic acid (Meyer, Smyth & Dawson, 1939) and its hexosa...

Hyaluronic acid is widely used in medical procedures, particularly in cosmetic procedures administered by physicians or nonmedical personnel. The materials used for cosmetic procedures by physicians as well as illegally by non-medical personnel can cause nonthrombotic pulmonary embolism (NTPE). We report the case of a woman with acute respiratory failure, neurologic symptoms and petechiae after...

Introduction Systemic juvenile idiopathic arthritis (JIA) is a subtype of childhood arthritis associated with significant systemic inflammation as well as arthritis. Hyaluronic acid as a constituent of connective tissue has previously been described as a marker for arthritis in JIA in an Asian population. Mutations in hyaluronic acid synthase 2 leading to accumulation of hyaluronic acid have be...

It has been shown that intravenously injected bovine testicular hyaluronidase reduces ischemic myocardial necrosis in animal models of myocardial infarction. The mechanism for the protective effect of hyaluronidase is unknown, but it has been suggested that this enzyme depolymerizes myocardial hyaluronic acid and thus improves interstitial transport. However, biochemical data showing that intra...

BACKGROUND Wound healing after endoscopic sinus surgery may result in adhesion formation. Hyaluronic acid may prevent synechiae development. A systematic review was performed to evaluate the current evidence on the clinical efficacy of hyaluronic acid applied to the nasal cavity after sinus surgery. METHODS Studies using hyaluronic acid as an adjunct treatment following endoscopic sinus surge...

Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans CPS1 gene, which is required for a capsular layer on the outer cell wall. In this report, we investigate the function of the CPS1 gene and its pathogenesis. We demonstrated that treatment of yeast with either 4-methylum...

BACKGROUND We developed an experimental model of ethanol-induced dermatotoxicity and hepatocytoxicity using normal human keratinocytes and normal human hepatocytes that preserve inducible cytochrome p450 activities. The original work was described in several articles. The objective of this study was to determine whether hyaluronic acid attenuates skin necrosis, and to further clarify its uses i...