The intra-articular injection of hydrocortisone acetate is commonly used in the treatment of osteoarthritis, although its action in this disease has received less careful study than in rheumatoid arthritis. In 1955 a less soluble ester, hydrocortisone tertiary-butylacetate (TBA) was developed for intraarticular therapy with the claim that its effects were more pronounced and of longer duration ...

OBJECTIVE To determine the efficacy and tolerability of topical pimecrolimus and tacrolimus compared with other treatments for atopic dermatitis. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic searches of the Cochrane Library, Medline, and Embase. STUDY SELECTION Randomised controlled trials of topical pimecrolimus or tacrolimus reporting efficacy outcomes or tolerabi...

A 27-month-old female cat was presented with septic peritonitis secondary to a ruptured pyometra and subsequent pyothorax. Vasopressor-refractory septic shock led to a suspicion of critical illness-related corticosteroid insufficiency, successfully treated with intravenous hydrocortisone. Previous megestrol acetate administration may have played a role in the development of adrenocortical dysfu...

Previously the author carrid out the intravenous glucose tolerance test with rats, and reported that the glucose tolerance curve for the adrenalectomized animal returned to the pre-operative level on the administration of hydrocortisone acetate (Tobe, 1957). Recently new compounds representing modifications of cortisone and hydrocortisone have appeared. Fried and Sabo(1953, 1954)showed that hal...

Many steroid hormones will depress the secretion of hydrocortisone by the adrenal by inhibiting secretion of pituitary corticotrophin. This inhibition has proved a useful means of demonstrating an intact pituitary-adrenal axis, and may help to distinguish between adrenal cortical neoplasia and hyperplasia (Jailer, Gold, and Wallace, 1954; Cope, 1956). However, most of these hormones are of litt...

Adrenal necrosis has been described in golden hamsters where it occurs during the course of infection with Besnoilia jellisoni. This necrosis results directly from the active intracellular proliferation by this obligate intracellular protozoan organism. After infection, adrenal necrosis is rarely observed in hypophysectomized hamsters. In unoperated animals adrenal necrosis is suppressed to var...

The discovery of the therapeutic properties of certain steroids has recently given rise to interesting chemical and pharmacological problems. The remarkable antiphlogistic activities of halogenated derivatives of hydrocortisone, and the disappearance of secondary effects obtained by the A1-diene derivatives of cortisone, have suggested the synthesis of a steroid which joins the two chemical cha...

During the past 31 years we have given more than 17,000 intrasynovial injections of hydrocortisone (Compound F) into the joints, bursae, or tendon sheaths of nearly 1,300 patients for various forms of rheumatic disease (Hollander and others, 1951a, 1954; Brown and others, 1953; Hollander, 1953a,b). Numerous confirmatory and supplementary reports in the world medical literature have shown that t...

Among the pharmacological problems raised by the study of the biological properties of cortisone is the existence of other substances exhibiting the same or similar properties. Hydrocortisone is already in practical use, and although not much more active than cortisone, in the acetate form it presents greater local antiphlogistic activity. Aldosterone which has been introduced into medical use ...