The purpose of our study was to achieve the gastro-retentive delivery Clarithromycin by producing floating pellets get a better therapeutic effect against gastrointestinal ulcers mostly caused Hedyotis pylori. Thereby were prepared utilizing blending polymers such as Sodium (Na) Alginate and Hydroxy Propyl Methyl Cellulose (HPMCK4M & HPMC K100LV). HPMC-alginate blend containing produced hyd...

The repair of peripheral nerve injuries is still one of the most challenging tasks and concerns in neurosurgery. Effect of methylprednisolone-laden hydrogel loaded into a chitosan conduit on the functional recovery of peripheral nerve using a rat sciatic nerve regeneration model was assessed. A 10-mm sciatic nerve defect was bridged using a chitosan conduit (CHIT/CGP-Hydrogel) filled with CGP-h...

Wharton’s jelly mesenchymal stem cells (HWJMSCs) hold promise for myocardial regeneration, but optimal treatment regimen (preferably with a growth factor) is required to maximize functional benefits. The aim of this study was to explore the cardioprotective and angiogenesis effects of HWJMSCs combined with insulin-like growth factor-1 (IGF-1) in the treatment of acute myocardial infarction. Th...

The aim of this study was to develop a stable hydrogel carrier system for thyme essential oil (TEO) that could protect its sensitive polyphenol compounds. impact wall material (soy protein and alginate) on encapsulation efficiency thymol release in simulated gastrointestinal conditions, investigated. ~ 80 % 20 gastric pancreatic solutions, respectively. Thyme plays an important role as antimicr...

microencapsulation has become a common technique in the production of controlled release dosage forms. many results have been reported, concerning the use of alginate beads as controlled release drug formulations. alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

suspension polymerization processes are significantly important in polymer bead formation. one of the important factors for bead size control in these processes is variation in surface tension. in this research, the prediction of optimum concentration of a surface active agent was investigated on the basis of the experimental surface tension diagrams. the experimental data show that the desired...

A new way is demonstrated to develop a bio-inspired coacervate hydrogel by following catechol chemistry showing injectable and re-moldable physical properties. The formed coacervate shows potential long-term stability under water. Depending on pH, formation of the coacervate has been verified which is confirmed by XPS and zeta potential measurements.

conclusions this study showed that compared to standard drug treatment, treatment with hydrogel containing peptide had substantial antibacterial effects on s. aureus wound infections in mice. results the highest and lowest numbers of wounds were observed on day 2 in the negative and positive control groups, respectively. during the 8-day period, the positive control and hydrogel containing pept...

cell-based biosensors have become a research hotspot in biosensors and bioelectronics fields. the main feature of cell-based biosensors is the immobilization of living cell on the surface of transducers. different types of polymers which are used as scaffolds for cell growth should be biocompatible and have reactive functional groups for further attachment of biomolecules. in this work, the cel...