INTRODUCTION Neurofibromatosis type 2 (NF2) is mainly associated with central nervous system (CNS) tumors. Peripheral nerve involvement is described in symptomatic patients, but evidence of subclinical peripheral nerve involvement is scarce. METHODS We conducted a cross-sectional pilot study in 2 asymptomatic and 3 minimally symptomatic patients with NF2 to detect subclinical peripheral nerve...

OBJECTIVES To evaluate the safety and efficacy of adding ciclosporin A (CSA) to the treatment of patients with psoriatic arthritis (PsA) demonstrating an incomplete response to methotrexate (MTX) monotherapy. METHODS In a 12 month, randomised, double blind, placebo controlled trial at five centres in three countries, 72 patients with active PsA with an incomplete response to MTX were randomis...

Diagnosis and differentiation of branchial cleft anomalies rest on higher imaging modalities such as computed tomography (CT) or magnetic resonance imaging (MRI). However, anatomical knowledge and meticulous characterization of anomaly on high resolution ultrasonography (HRUS) can clinch the diagnosis in most cases. Anomalies of the second branchial cleft account for 90% of the developmental ab...

BACKGROUND High-resolution ultrasonography (HRUS) has been used to diagnose carpal tunnel syndrome (CTS) in recent years. However, the best diagnostic criterion and optimal cut-off value for HRUS remain controversial. METHODS This study enrolled 37 patients with idiopathic CTS (61 CTS hands) and 20 healthy subjects (40 normal hands). The subjects underwent nerve conduction studies along with ...

OBJECTIVE To compare the diagnostic performance of high-resolution ultrasound (HRUS) with contrast-enhanced CT and contrast-enhanced magnetic resonance imaging (MRI) with MR cholangiopancreatography (MRCP) to differentiate between adenomyomatosis (ADM) and gallbladder cancer (GBCA). MATERIALS AND METHODS Forty patients with surgically proven ADM (n = 13) or GBCA at stage T2 or lower (n = 27) ...

Introduction: Resource managers need spatially explicit models of hydrologic response to changes in key climatic drivers across variable landscape conditions. We demonstrate the utility of a Basin Characterization Model for California (CA-BCM) to integrate high-resolution data on physical watershed characteristics with historical or projected climate data to predict watershed-specific hydrologi...