Gold nanoparticle self-assembled monolayers were fabricated by a sequential anchoring mechanism with rigid arenedithiol chemical linkers. These particle surface assemblies exhibited well-defined quantized capacitance characters in aqueous solutions, and more importantly, in aqueous solutions, the voltammetric responses were rectified in the presence of hydrophobic anions, which was interpreted ...

Packaging clinically relevant hydrophobic drugs into a self-assembled nanoparticle can improve their aqueous solubility, plasma half-life, tumour-specific uptake and therapeutic potential. To this end, here we conjugated paclitaxel (PTX) to recombinant chimeric polypeptides (CPs) that spontaneously self-assemble into ∼60 nm near-monodisperse nanoparticles that increased the systemic exposure of...

Amphiphilic boronic acid (BA)-substituted block copolymers have been utilized in biomedical applications through binding to saccharides, including glucose whereas the anaerobically produced metabolite lactate is unreported. Glucose requires basic conditions, while occurs at neutral physiological conditions. Herein, BA and used for first time convert solvated hydrophobic homopolymer amphiphilic ...

The development of vehicles for the co-encapsulation actives with diverse characteristics and their subsequent controllable co-delivery is gaining increasing research interest. Predominantly centred around pharmaceutical applications, majority such approaches have been focusing on solid formulations less so liquid-based systems. Simple emulsions can be designed to offer a microstructural platfo...

The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug delivery strategies and is of equal importance for toxicological considerations. Therefore, a detailed understanding of nanoparticle interaction with the stru...

Nanotechnology is a relatively new branch of science that involves harnessing the unique properties of particles that are nanometers in scale (nanoparticles). Nanoparticles can be engineered in a precise fashion where their size, composition and surface chemistry can be carefully controlled. This enables unprecedented freedom to modify some of the fundamental properties of their cargo, such as ...

This study proposes a new concept of pH-sensitive poly(lactide-co-glycolide) (PLGA) nanoparticle composite microcapsules for oral delivery of insulin. Firstly, insulin-sodium oleate complex was prepared by the hydrophobic ion pairing method and then encapsulated into PLGA nanoparticles by the emulsion solvent diffusion method. In order to reduce the burst release of insulin from PLGA nanopartic...

Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic ac...

We present a coarse-grained model for evaluation of interactions of globular proteins with nanoparticles (NPs). The protein molecules are represented by one bead per aminoacid and the nanoparticle by a homogeneous sphere that interacts with the aminoacids via a central force that depends on the nanoparticle size. The proposed methodology is used to predict the adsorption energies for six common...

The effect of enhancement the hydrophobic properties ensemble micro- and nanostructures ZnO as a result coating with gold was discovered. For first time, it has been shown that nanoparticle layer leads to sharp increase in wetting edge angle from 145 168 ° (water drop volume 5 mm3) decrease hydrophobicity/hydrophilicity transition time under ultraviolet irradiation. Keywords: ZnO, gold, superhy...