In response to various stress stimuli, heat shock genes are induced to express heat shock proteins (Hsps). Previous studies have revealed that expression of heat shock genes is regulated both at transcriptional and posttranscriptional level, and the rapid transcriptional induction of heat shock genes involves activation of the specific transcription factor, heat shock factor 1 (HSF1). Furthermo...

Hypoxia-inducible factor (HIF)-2α is considered to play a major role in the progression of osteoarthritis. Recently, it was reported that pressure amplitude influences HIF-2α expression in murine endothelial cells. We examined whether hydrostatic pressure is involved in expression of HIF-2α in articular chondrocytes. Chondrocytes were cultured and stimulated by inflammation or hydrostatic press...

The preferential association of cholesterol and sphingolipids within plasma membranes forms organized compartments termed lipid rafts. Addition of caveolin proteins to this lipid milieu induces the formation of specialized invaginated plasma membrane structures called caveolae. Both lipid rafts and caveolae are purported to function in vesicular transport and cell signaling. We and others have ...

Hydrostatic pressure is an important, ubiquitous, environmental variable of particular relevance in the marine environment. However, it is widely overlooked despite recent evidence that some marine ectotherms may be demonstrating climate-driven bathymetric range shifts. Wide-ranging effects of increased hydrostatic pressure have been observed from the molecular through to the behavioural level....

In this research the stress-strain curve of porous Titanium, as a common material for biomedical application, was predicted using the mechanical properties of fully solid Titanium experimental data. Modified Gurson model (Gurson-Tvergaard-Needleman (GTN) model) was used to predict the plastic response of porous Titanium in compaction. Different values of GTN parameters were used for different i...

BASED ON THE FIELD EQUATION for the number density of voids and the expression for the expansion of a spherical void in a perfectly plastic infinite body subjected to a uniform hydrostatic tensile stress, an expression for the rate of dilatation of voids is derived. Damage is defined as the volume density of voids. The flow stress of the material is assumed to decrease affinely with an increase...

This paper deals with the propagation of magneto-thermo Rayleigh waves in a homogeneous viscoelastic half-space under initial stress. It has been observed that velocity of Rayleigh waves depends on viscosity, magnetic field, temperature and initial stress of the half-space. The frequency equation for Rayleigh waves under the effect of magnetic field, stress and temperature for both viscoelastic...

The mechanism for nucleation phenomenon in solid-state microcellular foams is identified as a solid-state failure process. This process originates at internal flaws within the gas-polymer matrix, where it is induced by the presence of a state of hydrostatic tensile stress within the polymer matrix. The hydrostatic tensile stress is caused by the presence of the saturating gas within the polymer...

PURPOSE This study aimed to investigate and compare the residual ridge resorption (RRR) induced by an implant-retained overdenture (IRO) and associative biomechanics and by a conventional complete denture (CD) without implants. MATERIALS AND METHODS Cone beam computed tomography was used to quantify RRR in a three-dimensional (3D) manner before and after 1 year of treatment with either IROs o...

BACKGROUND Loads acting on scoliotic spines are thought to be asymmetric and involved in progression of the scoliotic deformity; abnormal loading patterns lead to changes in bone and disc cell activity and hence to vertebral body and disc wedging. At present however there are no direct measurements of intradiscal stresses or pressures in scoliotic spines. The aim of this study was to obtain qua...