The importance of career development has long been recognised in both academic and applied organisational settings. Yet the subject remains highly topical, particularly in environments that are characterised by wide-scale organisational and cultural change. The main aim of this paper is to highlight and explore, through the use a case study of the Estonian civil service, some of the key career-...

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extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. it is convenient for older patients to take only one tablet a day. marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. therefore, a less complicated...

Energetically favourable conformations for simultaneous intramolecular rotations of both the 17 a ethyl side chain and the 17 ß hydroxyl group of a model steroid are calculated by MM2 molecular mechanics. In accordance with recent IR and NMR interpretations, the 17a substituent is found to preferably adopt conformations which may sterically hinder the formation of hydrogen bonds between the ste...

Two bioactive coumarins including 7-hydroxycoumarin (umbelliferone) and 7-hydroxyl-6-methoxy-3, 70-dicoumarylether (daphnoretin) were separated from the ethyl acetate extract of the stems of Edgeworthia chrysantha Lindl (E. papyrifera) by high speed countercurrent chromatography (HSCCC). The two-phase solvent system used was composed of n-hexane-ethyl acetate–methanol–water at an optimized volu...

Six new chromones, 6-methoxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethyllchromone (2), 6,8-dihydroxy-2-(2-phenylethyl)chromone (3), 6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (4), 6-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (5), 7-hydroxy-2-(2-phenylethyl)chromone (6), and 6-hydroxy-7-methoxy-2-(2-phenylethyl)chromone (7) were isolated from the ether extract of agarwood in addition to a known ...

Neurosurgery requires the use of osmotic agents to reduce intracranial pressure which can adversely affect coagulation. Thromboelastography provides early indicator of derangement of coagulation. A prospective, non randomized pilot study was conducted to compare the effect of administration of either mannitol or hypertonic saline and when combined with hydroxy ethyl starch on coagulation and pl...