AIM The autosomal recessive hypercholesterolemia (ARH) gene is located on chromosome 1p35 and encodes a 308-amino acid protein containing a phosphotyrosine-binding domain. Several researchers have identified mutations of ARH that cause autosomal recessive hypercholesterolemia; however, it remains unknown whether this gene is involved in common hypercholesterolemia. METHODS AND RESULTS We sear...

Hypercholesterolemia induces renal inflammation and neovascularization, associated with renal endothelial dysfunction and injury. Neovascularization might conceivably represent a defense mechanism to sustain renal perfusion. Therefore, the present study was designed to test the hypothesis that preventing neovascularization using thalidomide, a potent anti-inflammatory and antiangiogenic agent, ...

OBJECTIVE To determine the extent to which patients' awareness, treatment, and control of hypertension and hypercholesterolemia have changed over time and to examine factors associated with awareness and treatment in a type 1 diabetes population. RESEARCH DESIGN AND METHODS Data from six examinations conducted over 10 years from the Pittsburgh Epidemiology of Diabetes Complications Study, a p...

The microcirculatory changes caused by hypercholesterolemia were studied in the rat cremaster muscle model by intravital microscopy and were compared with aortic ring segments from the same animals. Male Sprague-Dawley rats were fed either a normal chow diet or a chow diet supplemented with 1% cholesterol and 0.5% cholic acid for 3 or 5 weeks before experimentation. Three weeks of hypercholeste...

Pitavastatin((+)-monocalciumbis(3R,5S,6E)-7[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl3,5-dihydroxy-6-heptenoate]) (C50H46CaF2N2O8), is an entirely synthetic statin with a molecular weight of 880.98, that was initially developed by Nissan Chemical Industries Ltd., Tokyo, Japan, and later by Kowa Co. Ltd., Tokyo, (Figure 1).15 Pitavastatin exerts its potent pharmacological actions by strongly b...

background: diabetes mellitus type 2 with dyslipidemia is a common disease. previous studies suggest that chemical constituent present in pinus eldarica (p. eldarica) nut posesess antioxidant properties and positively affect glucose metabolism. however blood glucose and cholesterol lowering effects of p. eldarica nut have not been studied so far. objective: the present study was undertaken to e...

paliurus spina-christi mill (rhamnaceae) has been used in folk medicine as a hypocholesterolemic agent. in this study, the effect of total fruit extract on lowering lipid content of serum was investigated. male rats were introduced streptozocin, subsequently fed with a high cholesterol diet and concomitantly treated with various doses of the extract. after 8 days, serum levels of cholesterol, t...

The data in this relies on a previous publication: "Altered leukocyte distribution under hypercholesterolemia: a cross-sectional study in children with familial hypercholesterolemia" (Christensen et al. 2016) [1]. In the present paper, whole blood leukocyte distribution and plasma inflammatory proteins were measured for association with cholesterol concentration and CRP in children with familia...

The aims of this study were to examine the presence of mutations in the low-density lipoprotein receptor gene among subjects clinically diagnosed with familial hypercholesterolemia and to analyze whether the molecular diagnosis helps to predict the response to simvastatin treatment in our familial hypercholesterolemia population. Fifty-five probands and 128 related subjects with familial hyperc...