The Blueprint Genetics Hyperlipidemia Panel is ideal tool for genetic analysis of patients with virtually any type of monogenic (Mendelian inheritance) dyslipidemia disorder. All classical familial hypercholesterolemia (FH) genes (APOB, LDLR, LDLRAP1 and PCSK9) as well as genes associated with other hyperlipidemias such as ‘type 3 hyperlipidemia’ (APOE), sitosterolemia (ABCG5, ABCG8), lipoprote...

Hyperlipoproteinemia can aggravate glomerulosclerosis and chronic tubulointerstitial (ti) damage in kidneys without primary immunologic disease. We evaluated whether the effect of hyperlipidemia on progression of renal damage differed between kidneys without preexisting glomerular disease and kidneys with mesangioproliferative glomerulonephritis and whether the renal actions of hyperlipidemia w...

Hyperlipidemia is a condition of elevated lipid level in blood. Hyperlipidemia may be defined by serum total cholesterol >240mg/dL and/or LDL cholesterol >160mg/dL and/or total cholesterol: HDL ratio >5.7 and/or total triglycerides > 150mg/dL in adults. Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis related conditions like coronary heart disease (CHD), ischemic cerebrova...

The disabling pathophysiologic effects of lipid and neuroprotective effects of statins have recently been demonstrated for acute spinal cord injuries in animal models. This large scale population-based study aimed to investigate the effect hyperlipidemia and the use of statins in patients with lumbar spine injury. The National Health Insurance Research Database of Taiwan was used to identify pa...

diabetes is a common metabolic disease in the world that has many adverse effects. olibanum gum resin (from trees of the genus boswellia) has traditionally been used in the treatment of various diseases such as diabetes. the aim of this study was the comparison of olibanum gum resin effect with placebo on the treatment of type 2 diabetes. inclusion criteria was diabetic patients with fasting bl...

noncommunicable diseases pose a real threat to and their incidence is forecast to increase in both developed and developing countries; and, diabetes, obesity, and related complications are predicted to pose a great burden on health care systems all across the world. however, current used conventional medications and surgical interventions fall short of effectively controlling the rampant spread...

background: type 2 diabetes mellitus with hyperlipidemia is a common disease. conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. previous studies suggest that fiber-free artichoke (cynara scolymus l.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholest...

objective(s):lead (pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. materials and methods: here, we investigated the effect of chronic exposure to pb (50 mg/l) on oxidative stress, hepatotoxicity, nephrotoxicity, and lipid profile of two different age groups of female ra...

objective: persian leek is one of the most widely used herbal foods among iranians. in this study, effects of oral administration of persian leek on plasma and liver lipids were examined in hamster. materials and methods: male syrian hamsters were randomly divided into three groups: control (standard diet), high fat control (high-fat/high-cholesterol diet), persian leek (high-fat/high-cholester...

conclusions ehp was able to both reduce ldl-ch and to significantly decrease markers of oxidative stress and lipid peroxidation induced by hyperlipidemia. therefore, this herb, as a new pharmacological component, could be used to reduce certain blood lipids, lipid peroxidation, and aminotransferase markers. materials and methods thirty-two male rats weighting 200 ± 10 g were randomly divided in...