Hyperlipidemia is a medical condition characterized by an increase in one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids and or plasma lipoproteins including very low-density lipoprotein and low-density lipoprotein along with reduced high-density lipoprotein levels. This elevation of plasma lipids is among the leading risk factors associate...

OBJECTIVE To review the efficacy and safety of fenofibrate in the management of hyperlipidemias. DATA SOURCES A MEDLINE search (1974-October 1998), Current Contents search, additional references from article bibliographies, and the package insert from the manufacturer were used to identify data for evaluation. Studies evaluating fenofibrate (peer-reviewed publications, package insert data) we...

Niacin has long been prescribed for the treatment of various cardiovascular conditions, particularly the hyperlipidemias. It has been proven effective at lowering VLDL, LDL, total cholesterol and triglyceride levels while raising HDL levels. The side effects of niacin which may occur at the dosages often required for therapeutic efficacy, ranging from flushing and pruritus to hepatoxicity and i...

Background and Aims : To identify common rare genetic variants in APOE gene a cohort of subjects with primary hyperlipidemia compare them general population.Methods: A total 3180 unrelated consecutive were recruited the Lipid Unit at Hospital Universitario Miguel Servet, Zaragoza, Spain. Patients divided according to their lipid phenotype. 1426 patients diagnosed isolated hypercholesterolemia i...

Background: The Lipid Regulatory Hypothesis (LRH) states that the best way to regress atherosclerotic plaque is to simultaneously decrease the cholesterol being transported into the arterial wall by low-density lipoprotein (LDL) and increase the cholesterol being removed from the arterial wall, via reverse cholesterol transport, by high-density lipoprotein (HDL). The cholesterol retention fract...

Lipid apheresis is at present well established in routine treatment of diverse hyperlipoproteinemias refractory to conventional dietary and medical regimens, especially in countries with high medical and socioeconomic standards. Severe familial hypercholesterolemia with atherosclerotic vessel disease involving the coronary arteries is the most frequent indication for lipid apheresis as well as ...

Artificial Intelligence (AI), especially expert systems technology, has very promising possibilities for more fully automating the analysis of medical research data. The Program on the Surgical Control of the Hyperlipidemias (POSCH), a national multi-centered clinical trial has been experimenting with using AI in its data analyses for several years. Three projects are described in this paper. T...

Recent evidences suggest that human gut microbiota with major component as bacteria can induce immunity. It is also known that gut lining depletes with ageing and that there is increased risk of autoimmune and inflammatory disorders with ageing. It is therefore likely that both may be correlated as depletion of gut lining exposes the gut bacterial antigens to host immune mechanisms, which may i...

Diabetes mellitus (DM) is a protean metabolic disorder that adversely affects the vascular channels of the body leading to occlusive vascular events like coronary artery disease (CAD) and peripheral vascular disease (PVD).Besides the diabetic state, higher levels of triglycerides, lower HDL cholesterol and more of glycated Apo B100 contributes to the excess of atherogenesis in these subjects. I...