BACKGROUND It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing within this 3-week period. METHODS We performed a prospective study of 383 paediatric burns treated non-operatively at a regional burns centre over a 2-year...

Hypertrophic scar has always been the top priority of post-burn intervention. Specialists from multiple disciplines have dedicated enormous efforts expanding the knowledge in understanding the etiology of hypertrophic scar formation and establishing the scientific evidence of effective management of hypertrophic scar. The devotion and pursuit of these scientists and clinicians has been especial...

purpose our study aims to investigate the effectiveness of other treatment methods for burn related scarring and to determine the possibility of their routine administration in similar clinical settings. methods through a prospective study, 66 patients were enrolled to receive either the conventional pressure garment therapy (pgt) and silicone (control group) or exercise and physiotherapy (case...

BACKGROUND Hypertrophic scar following a burn is caused by the excessive deposit of collagen resulting in an exaggerated wound healing response. The burn patient complains of pain and itching over the scar, which can give rise to cosmetic and functional problems. OBJECTIVE The aim of this study was to investigate the clinical and histological correlation of a hypertrophic burn scar for itchin...

BACKGROUND A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars. METHODS A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). The efficacy of Silge...

Background and Design: The aim of this study is to investigate whether there can be a difference in types of scars developed on the same type of incisions due to cesarean section or benign gynecologic operations, and to examine the effect of regenerative process occurring in the puerperal period on scar formation. Materials and Methods: A total of 586 female patients aged 20-40 years, who appli...

BACKGROUND The calcium channel blocker, verapamil stimulates procollagenase synthesis in keloids and hypertrophic scars. AIM To study the effect of verapamil in the treatment of hypertrophic scars and keloids and to evaluate the effect of verapamil on the rate of reduction of hypertrophic scars and keloids in comparison with triamcinolone. METHODS The study was a randomized, single blind, p...

The functions and underlying mechanisms of homeobox B9 (HOXB9) in scar formation remain unclear; therefore, the present study aimed to investigate whether HOXB9 is highly expressed in hypertrophic scar formation. Immunohistochemistry was performed to examine the expression levels of laminin, fibronectin (FN), collagen type I (Col1) and HOXB9 in hypertrophic scar and healthy skin tissues, and in...

Hypertrophic and keloid scars are the result of unknown abnormalities in the wound healing process. The aim of this study was to develop physiologically relevant, human in vitro abnormal scar models for hypertrophic and keloid scars and compare these to normotrophic scars and normal skin to identify dierences in the pathogenesis of different scars. Keratinocytes and broblasts from normal skin a...

Hypertrophic scar formation is a result of adverse cutaneous wound healing. The pathogenesis of hypertrophic scar formation is still poorly understood. A problem next to the lack of suitable animal models is that often normal skin is compared to hypertrophic scar (HTscar) and not to normotrophic scar (NTscar) tissue. Another drawback is that often only one time period after wounding is studied,...