BACKGROUND Pressure therapy has been used to prevent and treat hypertrophic scars following cutaneous injury despite the limited understanding of its mechanism of action and lack of established animal model to optimize its usage. OBJECTIVES The aim of this work was to test and characterize a novel automated pressure delivery system designed to deliver steady and controllable pressure in a red...

Hypertrophic scars exhibit a higher prevalence within groups with darker skin tones. The Vancouver Scar Scale, patient and observer scar evaluation scale, high resolution ultrasound, Modified Scales, ultra-high frequency tonometry, multiphoton microscopy laser Doppler imaging are considered to be optimal tools for measurement of scar. therapeutic modalities employed the hypertrophic management ...

Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to t...

Corticosteroids are widely used as treatment for excessive scarring by intralesional injection with variable success rates. It is conceivable that systemically administered corticosteroids affect a wider range of inflammatory processes that influence wound healing and may be more successful in preventing hypertrophic scar formation. To study this presumption, we have used a standardized model o...

Rapid and better wound healing is an advantage of the laparoscopic approach compared with open surgery. The umbilicus a preferred site for port placement considering safety favorable cosmetic outcomes; however, postoperative management may be challenging owing to hypertrophic umbilical scars keloids (abnormal scars).

BACKGROUND Self-cutting using a razor blade is a type of self-mutilating behavior that leaves permanent and socially unacceptable scars with unique patterns, particularly on the upper extremities and anterior chest wall. These scars are easily recognized in the community and become a source of lifelong guilt, shame, and regret for the self-mutilators. In the presented clinical study, we aimed t...

BACKGROUND The calcium channel blocker, verapamil stimulates procollagenase synthesis in keloids and hypertrophic scars. AIM To study the effect of verapamil in the treatment of hypertrophic scars and keloids and to evaluate the effect of verapamil on the rate of reduction of hypertrophic scars and keloids in comparison with triamcinolone. METHODS The study was a randomized, single blind, p...

Basic fibroblast growth factor (bFGF) regulates skin wound healing; however, the underlying mechanism remains to be defined. In the present study, we determined the effects of bFGF on the regulation of cell growth as well as collagen and fibronectin expression in fibroblasts from normal human skin and from hypertrophic scars. We then explored the involvement of mitochondria in mediating bFGF-in...