The methanolic extract of Lycopus europaeus was evaluated on central nervous system. The methanolic extract produced significant sedative effect at the doses of 200, 400 and 600 mg/kg (by oral route), compared to reference substance diazepam in hole board and thiopental -induced sleeping time methods. While the hypnotic effect was calculated at the doses of 800 and 1000 mg/kg via oral pathway s...

Background: Insomnia, which is difficulty in initiating and maintaining sleep, is a very common experience for many people. Considering the increasing interest in medicinal plants in the past decade, many plants such as Coriandrum sativum, Salvia leriifolia, Salvia reuterana and Stachys lavanduli folia have been used in Iranian traditional medicine to abate insomnia. Objective: The present stu...

Pharmacokinetic studies of melatonin in young and elderly human volunteers, and the measurement of hypnotic effects in chicks under alternate light-dark or permanent light conditions, show that melatonin is a bioprecursor of hypnotic acetyl metabolites produced by the enzymatic acetylation of both melatonin and 2-oxomelatonin under the control of serotonin N-acetyltransferases (NATs), which are...

THIS review will treat the more commonly prescribed hypnotic agents and their sleep-inducing properties. Hypnotic agents that are seldom used (paraldehyde), drugs that are not singularly soporific but may be used either alone or as adjuncts in inducing sleep [e.g. meprobamate (Equanil, Miltown), chlordiazepoxide (Librium) and diazepam (Valium)] and drugs that have little soporific effect [antih...

Background: Coriandrum sativum L. has been recommended for relief of insomnia in Iranian traditional medicine. However, no pharmacological studies have yet evaluated its sedative effects. The aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity. Methods: The aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (10...

OBJECTIVE Previous studies suggested that slow injection of propofol may increase the hypnotic effect during induction of anesthesia. The aim of the present study was therefore to investigate whether injection rate of propofol has an influence on its maximum effect. DESIGN Randomized, single-blind trial. SETTING This study has been carried out in the operating rooms of a university hospital...

The hypnotic relationship is an important parameter for both experimental and therapeutic contexts. Hypnotic dreams may serve as a lens to examine the hypnotic relationship. By answering 5 questions per item, 70 judges rated 12 accounts of brief hypnotic dreams conducted as part of the Stanford Hypnotic Susceptibility Scale, Form C. The data show that the judges were able to correctly discern h...