Inflammatory bowel disease (IBD) is a chronic condition resulting in impaired intestinal homeostasis. Current practices for diagnosis of IBD are challenged by invasive, demanding procedures. We hypothesized that proteomics analysis could provide powerful tool identifying clinical biomarkers non-invasive diagnosis. Here, the global proteomes from commonly used vitro and vivo models were analyzed...

This study describes the initial testing of a novel strategy for neutralization of lentiviruses using the fundamental biology of enveloped viruses' assembly and budding. In the field of gene therapy, viral vector surface proteins have been manipulated in order to redirect host cell specificity by alteration of pseudo-types. This study tested whether known viral pseudo-typing proteins or surface...

Background Extracellular vesicles (EVs) are membrane-coated most often generated from the vasculature and circulating blood cells upon cell activation during early phase of apoptosis (1). Objectives To evaluate concentration different subpopulations EVs in plasma patients with SSc relation to disease duration markers endothelial injury. Methods Our study included 59 (36 limited (lSSc) 23 diffus...

TNFalpha (100 U/ml, 24 h) upregulated intercellular adhesion molecule 1 (ICAM1) expression on brain microvascular endothelial cell (BMEC) culture. The tyrosine kinase (TK) inhibitor genestein (100 microgram/ml), the protein kinase C (PKC) inhibitor staurosporin (1 nM), and interferon (IF) beta-1a (1000 U/ml) antagonized TNFalpha effect. When an ineffective dose of IFbeta-1a (100 U/ml) was chall...

The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated T-LBL onset while inhibiting progression to T-ALL. The T-LBL cells failed to invade the vasculature and showed evidence of increased homotypic cell-cell adhesion and autophag...

Objective(s): Fluvoxamine is a well-known selective serotonin reuptake inhibitor (SSRI); Despite its anti-inflammatory effect, little is known about the precise mechanisms involved. In our previous work, we found that IP administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. In this study, we aimed to evaluate the effect of fluvoxa...

Abstract BACKGROUND Glioblastoma (GBM) is an aggressive and highly fatal brain cancer in adults. Existing treatment methods are ineffective we need of new treatments that extend the overall survival improve quality-of-life. Cell adhesion molecules (CAMs) proteins enable cells to communicate with one another surrounding environment. Intracellular molecule 1 (ICAM1) a CAM expressed by TAMs GBM. T...

Soft scalar masses in supergravity with horizontal U(1) X gauge symmetry Abstract In supergravity with modular invariance and horizontal U (1) X gauge symmetry there is a relation between modular weights and U (1) X charges. The soft scalar masses are then strongly correlated with Yukawa matrices. The implications for FCNC are discussed.