The pharmacological profiles of the novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526) were investigated in terms of hog gastric H+,K+-ATPase activity, gastric acid secretion, and acute gastroesophageal lesions in comparison with other proton pump inhibitors (PPIs). CS-526 inhibited H+,K+-ATPase activity in ...

Telomelysin (OBP-301) is a telomerase-specific replication-component adenovirus. Telomelysin has a human telomerase reverse transcriptase (hTERT) promoter element which efficiently kills human cancer cells, but not normal cells. The present study investigated the correlation between the antitumor effect of telomelysin and mRNA expression of hTERT and coxsackievirus and adenovirus receptor (CAR)...

Fresh frozen plasma (FFP) is prepared in blood banks world-wide as a by-product of red blood cell concentrate preparation. Appropriate clinical use is for coagulation factor disorders where appropriate concentrates are unavailable and when multiple coagulation factor deficits occur such as in surgery. Viral safety depends on donor selection and screening; thus, there continues to be a small but...

in order to study the effect of water hardness on sinosulforun efficacy an experiment was carried out under controlled conditions in 2010 at the college of agriculture, ferdowsi university of mashhad. treatments included herbicides doses at 6 levels (0, 200, 250, 300, 350 and 400 g.a.i ha-1), calcium carbonate concentration at 6 levels (0, 100, 300, 600, 1000 and 1500 ppm) and weeds at 2 levels...

The inihibitory effect of various doses of ranitidine and cimetidine on pentagastrin stimulated volume, acid, and pepsin secretion was studied in 8 healthy volunteers. Both compounds inhibited all three variables in a dose dependent manner with an average ID50 of approximately 5 mg for ranitidine and of approximately 41 mg for cimetidine. On a molar basis ranitidine is about 11 times more poten...

Schmidt and Rasmussen (Proc. Soc. Exptl. Biol. Med., 81, 244, 1952) have shown that Co++ ions inhibit the multiplication of influenza A virus in embryonated eggs and that such inhibition was reversed when either histidine, infection with 100 to 500 ID50 of virus exerted a definite but transient suppressive effect on both influenza A and B viruses alike. Since cobalt was found (Child, Science, 1...

The susceptibility to infection with a Panamanian isolate of St. Louis encephalitis (SLE) virus was evaluated in Culex quinquefasciatus, Haemagogus equinus, Mansonia dyari, Sabethes cyaneus and Deinocerites pseudes. When fed on blood-virus suspensions using the hanging drop or pledget technique, the median infective dose (ID50) of SLE virus for colonized strains of Cx. quinquefasciatus and Hg. ...

A B S T R A C T Renal kallikrein is localized in luminal plasma membranes of the mammalian distal nephron and gains access to urine from this site. Its activity is regulated, in part, by aldosterone. These facts led us to study the effects of amiloride, a drug known to inhibit sodium reabsorption and potassium secretion at this site, on kallikrein activity. Amiloride inhibited the esterolytic a...

The drug accumulation of a human multidrug resistance 1 (mdr1) gene-transfected mouse lymphoma cell line and a multidrug resistance protein (MRP)-expressing human breast cancer cell line MDA-MB-231 was compared in the presence of sixteen flavonoids and five isoflavonoids. The expression of the 170-kDa P-glycoprotein (P-gp) (MDR1) and 190-kDa multidrug resistance protein (MRP) in both cell lines...