Fig. 1. X-ray of left forearm and hand showing osteosclerosis, ‘bone in bone’ appearance of shaft, fracture both bones, fraying and early cupping of metaphysis and widening of ‘physis’, the growth plate and absence of carpal bones. pathological fractures with ‘bone in bone’ appearance, increase in medullary density, defective metaphyseal remodeling with fraying and early cupping and widening of...

Disorders of calcium metabolism in childhood (except rickets) were regarded as uncommon until the recognition by Lightwood (1952) of the syndrome of 'idiopathic hypercalcaemia of infants with failure to thrive'. Previously there had been occasional reports of children considered to have AlbersSchonberg disease, hypervitaminosis D, primary hyperparathyroidism (Pratt, Geren and Neuhauser, 1947; P...

Osteosclerosis of the subchondral bone was measured by densitometer on plain radiographs in 55 medial compartmental osteoarthritic knees of 40 patients who were treated with high tibial valgus osteotomy for correction of varus deformity. The ratio of the osteosclerosis value of the medial side of the knee to that of the lateral side (Medial/Lateral ratio) was calculated and used as a parameter....

We have previously shown that mice induced to overexpress thrombopoietin (TPO) by retroviral-mediated gene transfer into bone marrow (BM) cells develop myelofibrosis and osteosclerosis. It was speculated that these effects were secondary to TPO, resulting from high levels of megakaryocytes and platelets. Also, it was proposed that these mice represent a model for myelofibrosis and osteosclerosi...

In multiple myeloma the typical bone lesions are usually purely osteolytic and the presence of any osteosclerosis suggests that the diagnosis should be reconsidered. There have now been reports of forty-nine patients with myeloma with osteosclerotic deposits in whom radiotherapy could not be implicated as a cause (Kr , Wiedermann, Vykydal and Soyka 1967; Evison and Evans 1967; Osuntokun, Akinku...

In communications to the British Paediatric Association in 1952, Lightwood and Payne described a group of 10 infants between the ages of 3 and 7 months presenting with anorexia, vomiting, failure to thrive, constipation and sometimes polyuria and polydipsia. They had hypercalcaemia, azotaemia and normal alkali reserves and in two of them radiographs showed nephrocalcinosis. There was no obvious...

The aim of this study was to determine the prevalence of idiopathic osteosclerosis (IO) and condensing osteitis (CO) in Zagreb patient population sample according to age and sex, localization in the jaw, as well as dental relationship between IO and CO lesions. A retrospective study was performed using orthopantomograms of 1200 patients who underwent dental treatment. Descriptive characteristic...

We have previously shown that mice induced to overexpress thrombopoietin (TPO) by retroviral-mediated gene transfer into bone marrow (BM) cells develop myelofibrosis and osteosclerosis. It was speculated that these effects were secondary to TPO, resulting from high levels of megakaryocytes and platelets. Also, it was proposed that these mice represent a model for myelofibrosis and osteosclerosi...