It is well established that individuals with bipolar disorder are differentially affected by substance-related as well as medical disorders (ie, cardiometabolic disorders, respiratory disorders, neurological disorders, and infectious diseases). Emerging evidence indicates that some comorbid conditions (eg, diabetes mellitus) in bipolar individuals may be subserved by overlapping neurobiological...

Objective(s):EMAP-like Protein 5 (EML5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. The aim of this study was to investigate the expression profile of EML5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (IE). Materials and Methods:Western blot assays were performed to determine EML5 expression in 36 su...

CONTEXT There is concern that exposure therapy, an evidence-based cognitive-behavioral treatment for posttraumatic stress disorder (PTSD), may be inappropriate because of risk of relapse for patients with co-occurring substance dependence. OBJECTIVE To determine whether an integrated treatment for PTSD and substance dependence, Concurrent Treatment of PTSD and Substance Use Disorders Using Pr...

1.2 Machine failure A system is composed of 5 components, each of which is either working or broken. Consider an experiment that consists of observing the status of each component, and let the outcome of the experiment be given by the vector (x1, x2, x3, x4, x5), where xi = 1 if component i works and 0 if component i is broken. 1. How many outcomes are in the sample space of this experiment? 2....

Neoplastic transformation is a complex process that results from multiple changes in gene activities. Probably most of these are mutational, i.e. alterations in the genomic structure of DNA, but others may be due to adaptive changes wherein genes are expressed that are inappropriate to a stage of development or differentiation. In this commentary neoplastic development is discussed in the conte...

le mouvement transversal de la locomotive ou des wagons , appele ie lacet, provient de deux causes principales: -la conicite des bandages -les irregularites de la voie dans ie plan horizontal. on se propose ici d'etudier la premiere cause , ce qui nous conduit a une equation differentielle non lineaire du deuxieme ordre. • l'equation en question est etudiee dans plusieurs cas difftten...