(-)-Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea, has recently been identified as an inhibitor of hepatitis C virus (HCV) entry. Here, we examined whether EGCG can enhance hepatocyte-mediated intracellular innate immunity against HCV. HCV dsRNAs (Core, E1-P7, NS-3'NTR and NS5A) induced interferon-λ1 (IFN-λ1) expression in human hepatocytes. These HCV dsRNAs also ...

Papillomaviruses are a group of DNA viruses belonging to the Papillomavirida family. These provoke pathological conditions manifesting with inflammation, exophytic masses, carcinogenesis, reproductive and perinatal disorders. Immune status is an essential factor de-termining severity duration inflammatory diseases, course latent viral infections, including papillomavirus infection (PVI). The hu...

Background: More than 768 million people have been affected by COVID-19. Identifying lymphocyte subsets and cytokine level abnormalities in COVID-19 patients is essential to gain new insights data on immunity mechanisms against viral infections. Objectives: We used flow cytometry determine the relationship between disease severity, distribution, alterations patients. Methods: Totally 94 (32 mil...

In vitro culture models that precisely mirror the porcine respiratory epithelium are needed to gain insight into how pathogens and host interact. this study, a new bronchial epithelial cell line, designated as PBE cells, was established from tract of neonatal pig. cells assumed cobblestone-epithelial like morphology with close contacts between when they reached confluence. The line characterize...